Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

APC/β-Catenin Pathway

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_348-2

Synonyms

The terms Wnt pathway and APC/β-catenin pathway have been used interchangeably. Because some Wnt proteins have β-catenin-independent effects, and since β-catenin can be affected by upstream pathways other than Wnt, the term APC/β-catenin is used here.

Definition

The APC/β-catenin pathway is a signal transduction pathway important in development and tumorigenesis. Signaling by this pathway is defined as the stabilization of β-catenin and transcriptional activation of several target genes.

Characteristics

β-Catenin is a multifunctional protein with roles in adhesion and signal transduction. The adhesion properties of β-catenin reflect its ability to interact with E-cadherinat the cellular membrane, and the alteration of this important cellular function has been associated with an increased invasion potential of cancer cells. In addition to this important role, β-catenin is also found in a cytoplasmic/nuclear pool and is believed to act as a signal transduction molecule....

Keywords

Familial Adenomatous Polyposis Nuclear Export Signal Inappropriate Activation Transcriptional Activation Domain Important Cellular Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Aberle H, Bauer A, Stappert J et al (1997) β-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16:3797–3804CrossRefPubMedPubMedCentralGoogle Scholar
  2. Morin PJ (1999) β-Catenin signaling and cancer. Bioessays 21:1021–1030CrossRefPubMedGoogle Scholar
  3. Morin PJ, Sparks AB, Korinek V et al (1997) Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275:1787–1790CrossRefPubMedGoogle Scholar
  4. Orford K, Crockett C, Jensen JP et al (1997) Serine phosphorylation-regulated ubiquitination and degradation of β-catenin. J Biol Chem 272:24735–24738CrossRefPubMedGoogle Scholar
  5. Peifer M, Polakis P (2000) Wnt signaling in oncogenesis and embryogenesis – a look outside the nucleus. Science 287:1606–1609CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Laboratory of Molecular Biology and ImmunologyNational Institute on AgingBaltimoreUSA
  2. 2.Department of Pathology, Oncology and Gynecology and ObstetricsJohns Hopkins Medical InstitutionsBaltimoreUSA
  3. 3.American Association for Cancer ResearchPhiladelphiaUSA