Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

APC/β-Catenin Pathway

  • Pat J. Morin
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_348-2


The terms Wnt pathway and APC/β-catenin pathway have been used interchangeably. Because some Wnt proteins have β-catenin-independent effects, and since β-catenin can be affected by upstream pathways other than Wnt, the term APC/β-catenin is used here.


The APC/β-catenin pathway is a signal transduction pathway important in development and tumorigenesis. Signaling by this pathway is defined as the stabilization of β-catenin and transcriptional activation of several target genes.


β-Catenin is a multifunctional protein with roles in adhesion and signal transduction. The adhesion properties of β-catenin reflect its ability to interact with E-cadherinat the cellular membrane, and the alteration of this important cellular function has been associated with an increased invasion potential of cancer cells. In addition to this important role, β-catenin is also found in a cytoplasmic/nuclear pool and is believed to act as a signal transduction molecule....


Familial Adenomatous Polyposis Nuclear Export Signal Inappropriate Activation Transcriptional Activation Domain Important Cellular Function 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Laboratory of Molecular Biology and ImmunologyNational Institute on AgingBaltimoreUSA
  2. 2.Department of Pathology, Oncology and Gynecology and ObstetricsJohns Hopkins Medical InstitutionsBaltimoreUSA
  3. 3.American Association for Cancer ResearchPhiladelphiaUSA