Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Lysophosphatidylcholine

  • Geum-Youn Gwak
  • Jung-Hwan Yoon
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3471-2

Synonyms

Definition

Lysophosphatidylcholine (LPC) is a major plasma lipid constituent that is produced from phosphatidylcholine (PC).

Characteristics

LPC is produced from PC under a variety of physiological and pathological conditions. LPC is present at high levels (about 100 μM) in plasma under normal conditions and exists mainly in albumin- or lipoprotein-bound forms. The biochemical conversion from PC to LPC is mediated by phospholipase A1 or phospholipase A2. Sequentially, LPC is converted to lysophosphatidate (LPA) by lysophospholipase D (autotaxin) (Fig. 1).

Keywords

Multiple Myeloma Biochemical Conversion Biliary Tract Carcinoma Serum Response Element Induce Cell Migration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Brindley DN (2004) Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer. J Cell Biochem 92:900–912CrossRefPubMedGoogle Scholar
  2. Gwak GY, Yoon JH, Lee SH et al (2006) Lysophosphatidylcholine suppresses apoptotic cell death by inducing cyclooxygenase-2 expression via a Raf-1 dependent mechanism in human cholangiocytes. J Cancer Res Clin Oncol 132:771–779CrossRefPubMedGoogle Scholar
  3. Meyer zu Heringdorf D, Jakobs KH (2007) Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim Biophys Acta 1768:923–940CrossRefPubMedGoogle Scholar
  4. Tomura H, Mogi C, Sato K et al (2005) Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors. Cell Signal 17:1466–1476CrossRefPubMedGoogle Scholar
  5. Xu Y (2002) Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. Biochim Biophys Acta 1582:81–88CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Anomalous pancreaticobiliary ductal junction. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 193. doi:10.1007/978-3-642-16483-5_290Google Scholar
  2. (2012) Cyclooxygenase-2. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1035. doi:10.1007/978-3-642-16483-5_1435Google Scholar
  3. (2012) Lysophosphatidate. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2126. doi:10.1007/978-3-642-16483-5_3470Google Scholar
  4. (2012) Phospholipase A1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2869. doi:10.1007/978-3-642-16483-5_4537Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSouth Korea
  2. 2.Department of Internal MedicineSeoul National University College of MedicineChongno-guSouth Korea