Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Geum-Youn Gwak
  • Jung-Hwan Yoon
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3471-2



Lysophosphatidylcholine (LPC) is a major plasma lipid constituent that is produced from phosphatidylcholine (PC).


LPC is produced from PC under a variety of physiological and pathological conditions. LPC is present at high levels (about 100 μM) in plasma under normal conditions and exists mainly in albumin- or lipoprotein-bound forms. The biochemical conversion from PC to LPC is mediated by phospholipase A1 or phospholipase A2. Sequentially, LPC is converted to lysophosphatidate (LPA) by lysophospholipase D (autotaxin) (Fig. 1).


Multiple Myeloma Biochemical Conversion Biliary Tract Carcinoma Serum Response Element Induce Cell Migration 
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See Also

  1. (2012) Anomalous pancreaticobiliary ductal junction. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 193. doi:10.1007/978-3-642-16483-5_290Google Scholar
  2. (2012) Cyclooxygenase-2. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1035. doi:10.1007/978-3-642-16483-5_1435Google Scholar
  3. (2012) Lysophosphatidate. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2126. doi:10.1007/978-3-642-16483-5_3470Google Scholar
  4. (2012) Phospholipase A1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2869. doi:10.1007/978-3-642-16483-5_4537Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSouth Korea
  2. 2.Department of Internal MedicineSeoul National University College of MedicineChongno-guSouth Korea