Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Lung Cancer

  • Adi F. Gazdar
  • John D. Minna
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3434-2

Synonyms

Definition

The term lung cancer is used for malignant epithelial tumors arising from the respiratory mucosa (bronchi, bronchioles, and alveoli). Mesotheliomas, lymphomas, and stromal tumors (sarcomas) are distinct from epithelial lung cancers.

Characteristics

Lung cancer is the leading cause of cancer death worldwide with over 1 million deaths each year. The disease is largely preventable as the majority of cases are attributable to smoking. However, global statistics estimate that 15 % of lung cancer cases in men and 53 % in women occur in never smokers.

The 5-year overall lung cancer survival rate (15 %) has nearly doubled in the past 30 years as a result of advances in combined-modality treatment with surgery, radiotherapy, and chemotherapy. Thus, primary carcinoma of the lung is a major health problem with a generally poor prognosis.

Pathology

Four major cell types make up 88 % of all primary lung neoplasms according to the World...

Keywords

Lung Cancer Tumor Suppressor Gene Small Cell Lung Cancer Epidermal Growth Factor Receptor Mutation Small Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Pass HI, Carbone DP, Johnson DH et al (2005) Lung cancer: principles and practice, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 1–933Google Scholar
  2. Sato M, Shames DS, Gazdar AF et al (2007) A translational view of the molecular pathogenesis of lung cancer. J Thorac Oncol 2:327–343PubMedCrossRefGoogle Scholar
  3. Sharma SV, Bell DW, Settleman J et al (2007) Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 7:169–181PubMedCrossRefGoogle Scholar
  4. Subramanian J, Govindan R (2007) Lung cancer in never smokers: a review. J Clin Oncol 25:561–570PubMedCrossRefGoogle Scholar
  5. Wistuba I, Gazdar AF (2006) Lung cancer preneoplasia. Annu Rev Pathol: Mech Dis 1:331–348CrossRefGoogle Scholar

See Also

  1. (2012) Adenocarcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 48. doi:10.1007/978-3-642-16483-5_84Google Scholar
  2. (2012) Allele. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 137. doi:10.1007/978-3-642-16483-5_6570Google Scholar
  3. (2012) Autocrine. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 311. doi:10.1007/978-3-642-16483-5_468Google Scholar
  4. (2012) Carcinogen. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 644. doi:10.1007/978-3-642-16483-5_839Google Scholar
  5. (2012) FHIT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1394. doi:10.1007/978-3-642-16483-5_2168Google Scholar
  6. (2012) Large cell carcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1980. doi:10.1007/978-3-642-16483-5_3280Google Scholar
  7. (2012) Loss of heterozygosity. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2075–2076. doi:10.1007/978-3-642-16483-5_3415Google Scholar
  8. (2012) MTOR. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2384. doi:10.1007/978-3-642-16483-5_3867Google Scholar
  9. (2012) Nicotine. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2518. doi:10.1007/978-3-642-16483-5_4080Google Scholar
  10. (2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331Google Scholar
  11. (2012) Palliative. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2759. doi:10.1007/978-3-642-16483-5_4350Google Scholar
  12. (2012) RB1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3189. doi:10.1007/978-3-642-16483-5_4964Google Scholar
  13. (2012) Small cell lung carcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3448. doi:10.1007/978-3-642-16483-5_5368Google Scholar
  14. (2012) Targeted therapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3610. doi:10.1007/978-3-642-16483-5_5677Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Hamon Center for therapeutic Oncology Research and Departments of Pathology, Internal Medicine and PharmacologyUniversity of Texas Southwestern Medical CenterDallasUSA