Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Lugol-Unstained Lesion

  • Kazuhiro Kaneko
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3431-2


In 1933, the Lugol-spraying method was introduced for the diagnosis of uterine cervical neoplasia using gynecologic colposcopy.

Since the 1980s, this technique has been used for screening of esophageal squamous cell carcinoma (ESCC) with Lugol chromoendoscopy. The Lugol-spraying method has developed for early detection of ESCC from asymptomatic patients.


After ordinary endoscopic observation, 5–10 ml of 2.0 % glycerin-free Lugol iodine solution, which is a brown liquid consisting of 2.0 g potassium iodine and 4.0 g iodine to 100 ml distilled water, is sprayed from the gastroesophageal junction to the upper esophagus using a plastic spray catheter passed through the biopsy channel of the endoscope. The whole esophagus is reobserved and epithelial areas are categorized as unstained (Fig. 1a, b), normally stained (Fig. 1c), or overstained (Fig. 1d). Lugol-unstained lesions (LULs) are defined as those areas either staining less intensely than normally stained...


Esophageal Squamous Cell Carcinoma Esophageal Squamous Cell Carcinoma Patient Esophageal Epithelium Basal Cell Hyperplasia Selective Growth Advantage 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Gastroenterology, Endoscopy DivisionNational Cancer Center Hospital EastChibaJapan