Definition
Activating protein-1 (AP-1) is a transcription factor usually consisting of a member of the Jun family and a member of the Fos or ATF family of proto-oncogenes. AP-1 is activated in response to cytokines, growth factors, and stress factors during cell differentiation, tumor formation, or mitogenic response.
Characteristics
Much of our present knowledge about transcription factors comes from the discovery and study of the activating protein-1 (AP-1) family. AP-1 (and the transcription factor NFκB) has served to detect one of the decisive DNA-binding motifs required for gene regulation by a variety of extracellular signals including growth factors, cytokines, tumor promoters, such as the phorbol ester TPA (12-O-tetradecanoyl-phorbol-13-acetate), and carcinogens, for example, UV irradiation and other DNA-damaging agents. One of its members, the heterodimer Fos-Jun, was found in the mid-1980s, as a protein complex containing the viral oncogeneproduct Fos without a clue of its...
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References
Eferl R, Wagner EF (2003) AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 3:859–868
Hess J, Angel P, Schorpp-Kistner M (2004) AP-1 subunits: quarrel and harmony among siblings. J Cell Sci 117:5965–5973
Shaulian E, Karin M (2002) AP-1 as a regulator of cell life and death. Nat Cell Biol 4:E131–E136
Wagner EF (2001) AP-1 reviews. Oncogene 20:2333–2497
Weston CR, Davis RJ (2002) The JNK signal transduction pathway. Curr Opin Genet Dev 12:14–21
See Also
(2012) Cellular Transformation Assay. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 743. doi: 10.1007/978-3-642-16483-5_1020
(2012) G-protein Couple Receptor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1587. doi: 10.1007/978-3-642-16483-5_2294
(2012) MAPK. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2167. doi: 10.1007/978-3-642-16483-5_3532
(2012) P53. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331
(2012) Polyubiquitination. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2957. doi: 10.1007/978-3-642-16483-5_4678
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Angel, P., Hess, J. (2015). AP-1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_341-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_341-2
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