Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Log-Kill Hypothesis

  • Tiffany A. Traina
  • Larry Norton
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3409-2



The log-kill hypothesis proposes a model for the effect of cytotoxic chemotherapy on tumor size. It states that a given dose of chemotherapy kills the same fraction of tumor cells regardless of the size of the tumor at the time of treatment.


Experimental and mathematical models have attempted to describe the fundamentals of tumor cell growth and kinetics. From these systems arose an improved understanding of tumor growth characteristics, a foundation for the key principles of chemotherapy, and, eventually, recognition of the importance of dose scheduling. The Skipper-Schabel-Wilcox model is one of the most influential and pioneering experiments in the history of oncology.

Investigators at the Southern Research Institute developed a simple model of tumor growth using L1210 murine leukemia cells. This system had two notable features: a seemingly exponential growth pattern and the ability to...


Adjuvant Therapy Early Stage Cancer Postoperative Setting Sensitive Population Pioneer Experiment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Chu E, DeVita V (2005) Principles of medical oncology. In: DeVita V, Hellman S, Rosenberg S (eds) Cancer principles and practice of oncology. Lippincott Williams and Wilkins, Philadelphia, pp 295–301Google Scholar
  2. Gilewski T, Dang C, Surbone A et al (2003) Cytokinetics. In: Holland J, Frei E (eds) Cancer medicine, 6th edn. BC Decker, HamiltonGoogle Scholar
  3. Traina TA, Hudis C, Norton L (2006) Dose-dense chemotherapy for breast cancer: a validation of the Norton-Simon hypothesis. In: De Vita VT Jr, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology updates. Lippincott Williams and Wilkins, Philadelphia. Chap 8Google Scholar

See Also

  1. (2012) Gompertzian Growth Curve. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1576. doi:10.1007/978-3-642-16483-5_2473Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Breast Cancer Medicine Service, Department of MedicineMemorial Sloan-Kettering Cancer CenterNew YorkUSA