Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Locoregional Therapy

  • Teh-Ia Huo
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3407-3

Synonyms

Definition

There has been no clear definition for locoregional therapy. Most often, locoregional therapy refers to various minimally invasive therapeutic procedures. With the aid of ultrasound guidance, an antitumoral device, drug, or chemical is introduced directly into the tumor and causes tumor death.

Characteristics

For most human cancers, surgical resection remains the standard treatment modality. However, resection is sometimes possible in only a minority of patients. When surgical treatment is less likely to perform, physicians may choose other therapeutic procedures. Among the available methods, locoregional therapy has been frequently used to treat cancer. It is so named because the tumors can often be treated locally. The best example to demonstrate the role and usefulness of locoregional therapy is applying this kind of therapy in patients with hepatocellular carcinoma, or HCC, which is a primary liver cancer originated from transformed liver...

Keywords

Percutaneous Ethanol Injection Locoregional Therapy Local Ablation Therapy Microwave Coagulation Therapy Adjacent Liver Parenchyma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Huo TI, Huang YH, Wu JC (2004) Comparison of transarterial chemoembolization and percutaneous acetic acid injection as the primary locoregional therapy for unresectable hepatocellular carcinoma: a prospective survey. Aliment Pharmacol Ther 19:1301–1308CrossRefPubMedGoogle Scholar
  2. Lau WY, Leung TW, Yu SC (2003) Percutaneous local ablative therapy for hepatocellular carcinoma: a review and look into the future. Ann Surg 237:171–179PubMedPubMedCentralGoogle Scholar
  3. Llovet JM, Bruix J (2003) Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology 37:429–442CrossRefPubMedGoogle Scholar
  4. Llovet JM, Burroughs A, Bruix J (2003) Hepatocellular carcinoma. Lancet 362:1907–1917CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institute of Pharmacology, School of MedicineNational Yang-Ming UniversityTaipeiTaiwan