Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Hepatocellular Carcinoma Molecular Biology

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3394-2

Definition

Primary liver cancer includes four major histological tumor types: (i) the most frequent form is hepatocellular carcinoma (HCC), a malignant epithelial neoplasm that develops from hepatocytes (the basal liver parenchymal cells); (ii) hepatoblastoma is a rare embryonic liver tumor arising from immature hepatocytes, mainly in children under 2 years of age; (iii) intrahepatic cholangiocarcinoma (ICC) develops from the epithelium of intrahepatic biliary ducts; and (iv) angiosarcoma is a rare malignant mesenchymal (vascular) tumor.

Characteristics

Epidemiology

HCC is one of the most common human tumors worldwide, with an estimate of 782,000 new cases diagnosed in 2012; it has an exceptionally high case fatality rate of 95 % (i.e., 746,000 deaths). The incidence of HCC varies widely according to geographical variation, sex, and age distribution. The highest incidence rates occur in Asia and Africa, but they are continuously rising in the United States and Europe. Approximately 75...

Keywords

Adenomatous Polyposis Coli Adenomatous Polyposis Coli Gene SFRP1 Gene Copy Number Alteration Analysis Recurrence Follow Liver Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

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  2. APC. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 234. doi:10.1007/978-3-642-16483-5_347Google Scholar
  3. Beta-catenin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 385. doi:10.1007/978-3-642-16483-5_88Google Scholar
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  7. Hepatitis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1663. doi:10.1007/978-3-642-16483-5_2658Google Scholar
  8. Insertional mutagenesis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1873. doi:10.1007/978-3-642-16483-5_3073Google Scholar
  9. LINE. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2041. doi:10.1007/978-3-642-16483-5_3359Google Scholar
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  11. P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331Google Scholar
  12. STAT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3502. doi:10.1007/978-3-642-16483-5_5481Google Scholar
  13. Wnt/beta-catenin pathway. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3957. doi:10.1007/978-3-642-16483-5_6256Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Miran Kim
    • 1
  • Marie Annick Buendia
    • 2
  • Jack R. Wands
    • 1
  1. 1.Division of Gastroenterology, Liver Research CenterRhode Island Hospital and Warren Alpert Medical School of Brown UniversityProvidenceUSA
  2. 2.Hopital Paul BrousseInserm U785, Centre HépatobiliaireVillejuifFrance