5-LOX is a nonheme iron dioxygenase that catalyzes the synthesis of a broad class of compounds, known as leukotrienes (LT), lipoxins, resolvins, and protectins.
In human beings, this enzyme is encoded by the Alox5 gene (Chromosome 10, Location 10q11.2).
Its substrates belong to the polyunsaturated fatty acids (PUFAs) family, mainly the ω-3 and ω-6, where 5-LOX inserts O2 in a regional-specific fashion.
From the ω-6 arachidonic acid (AA, 20:4n-6), the proinflammatory LTB4, LTC4, LTD4, LTE4, and lipoxins are formed; the anti-inflammatory LTB5, LTC5, LTD5, LTE5, and E-series resolvins derive from the ω-3 eicosapentaenoic acid (EPA, 20:5n-3); from the ω-3 docosahexaenoic acid (DHA, 22:6n-3), protectins and D-series resolvins are synthesized. Notwithstanding, the inflammatory or anti-inflammatory nature of these compounds is currently under revision, due to emerging contradictory role of 5-LOX products in both...
KeywordsPulmonary Microvascular Endothelial Cell Human Pulmonary Microvascular Endothelial Cell Vascular Endothelial Growth Factor Induction Breast Cancer Stem Cell Phenotype Human Brain Endothelial Cell Line
- Banerjee S, Tuncay S (2006) ALOX5 (Arachidonate 5-Lipoxygenase) Atlas of genetics and cytogenetics in oncology and hematology. http://AtlasGeneticsOncology.org/Genes/ALOX5ID42985ch10q11.html
- Taosheng C (2012) Interleukin-6. Encyclopedia of cancer. (Springer ed.) http://www.springerreference.com/docs/biopage/36365.html
- Tavolari S, Bonafè M, Marini M, Ferreri C, Bartolini G, Brighenti E, Manara S, Tomasi V, Laufer S, Guarnieri T (2008) Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis 29:371–380CrossRefPubMedGoogle Scholar