The central problem in cancer chemotherapy (Chemotherapy of Cancer, Progress and Perspectives) is the severe toxic side effects of anticancer drugs on healthy tissues. The use of liposomes as drug delivery vehicles (Drug delivery systems in cancer) for antitumor therapeutics has great potential to revolutionize the future of cancer therapy. As tumor architecture causes liposomes to preferentially accumulate at the tumor site, their use as drug carrier result in the localization of a greater amount of the drug load at the tumor site, thus improving cancer therapy and reducing the harmful nonspecific side effects of chemotherapeutics. In addition, targeting of liposomal anticancer drugs to antigens expressed or overexpressed on tumor cells provides a very efficient system for increasing the therapeutic indices of the drugs.
The Magic Bullet Concept
Within medical practice, there has long been the desire to achieve...