Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Liposomal Chemotherapy

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3387-2

Synonyms

Definition

The central problem in cancer chemotherapy (Chemotherapy of Cancer, Progress and Perspectives) is the severe toxic side effects of anticancer drugs on healthy tissues. The use of liposomes as drug delivery vehicles (Drug delivery systems in cancer) for antitumor therapeutics has great potential to revolutionize the future of cancer therapy. As tumor architecture causes liposomes to preferentially accumulate at the tumor site, their use as drug carrier result in the localization of a greater amount of the drug load at the tumor site, thus improving cancer therapy and reducing the harmful nonspecific side effects of chemotherapeutics. In addition, targeting of liposomal anticancer drugs to antigens expressed or overexpressed on tumor cells provides a very efficient system for increasing the therapeutic indices of the drugs.

Characteristics

The Magic Bullet Concept

Within medical practice, there has long been the desire to achieve...

Keywords

Malignant Pleural Mesothelioma Liposomal Doxorubicin Neoplastic Meningitis Liposomal Drug Conventional Liposome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Experimental Therapies Unit, Laboratory of OncologyIstituto Giannina GasliniGenoaItaly