Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Lipoma-Preferred Partner

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3380-2

Synonyms

Definition

Lipoma-preferred partner (LPP) is a LIM domain protein that belongs to the zyxin family of cytoskeletal adaptor proteins. LPP is localized in cellular adhesion sites and is in certain conditions also detected in the nucleus where it acts as a transcriptional coactivator. It is highly expressed in smooth muscle cells and plays a role in cell migration. In particular tumors, aberrant LPP proteins are expressed in which the LIM domains are fused to DNA-binding domains. These tumor-specific LPP fusion proteins function as transcription factors.

Characteristics

LPP and Tumors

Lipomas are benign tumors of adipose tissue and one of the most commonly occurring soft tissue tumors in humans. A minority of patients has multiple tumors, however most patients have only one tumor. More than 60 % of human solitary lipomas have an abnormal karyotype. Two thirds of the latter carry chromosomal aberrations, mostly...

Keywords

Mixed Lineage Leukemia HMGA2 Protein Translocation Partner Normal Mammary Gland Development Smooth Muscle Cell Marker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Gorenne I, Nakamoto RK, Phelps CP et al (2003) LPP, a LIM protein highly expressed in smooth muscle. Am J Physiol Cell Physiol 285:C674–C685CrossRefPubMedGoogle Scholar
  2. Guo B, Sallis RE, Greenall A et al (2006) The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3. Mol Cell Biol 26:4529–4538CrossRefPubMedPubMedCentralGoogle Scholar
  3. Nelander S, Mostad P, Lindahl P (2003) Prediction of cell type-specific gene modules: identification and initial characterization of a core set of smooth muscle-specific genes. Genome Res 13:1838–1854PubMedPubMedCentralGoogle Scholar
  4. Petit MMR, Mols R, Schoenmakers EF et al (1996) LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 36:118–129CrossRefPubMedGoogle Scholar
  5. Petit MMR, Fradelizi J, Golsteyn RM et al (2000) LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Mol Biol Cell 11:117–129CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Human GeneticsUniversity of LeuvenLeuvenBelgium