Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Lipoma-Preferred Partner

  • Marleen M. R. Petit
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3380-2



Lipoma-preferred partner (LPP) is a LIM domain protein that belongs to the zyxin family of cytoskeletal adaptor proteins. LPP is localized in cellular adhesion sites and is in certain conditions also detected in the nucleus where it acts as a transcriptional coactivator. It is highly expressed in smooth muscle cells and plays a role in cell migration. In particular tumors, aberrant LPP proteins are expressed in which the LIM domains are fused to DNA-binding domains. These tumor-specific LPP fusion proteins function as transcription factors.


LPP and Tumors

Lipomas are benign tumors of adipose tissue and one of the most commonly occurring soft tissue tumors in humans. A minority of patients has multiple tumors, however most patients have only one tumor. More than 60 % of human solitary lipomas have an abnormal karyotype. Two thirds of the latter carry chromosomal aberrations, mostly...


Mixed Lineage Leukemia HMGA2 Protein Translocation Partner Normal Mammary Gland Development Smooth Muscle Cell Marker 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Human GeneticsUniversity of LeuvenLeuvenBelgium