Lipoma-preferred partner (LPP) is a LIM domain protein that belongs to the zyxin family of cytoskeletal adaptor proteins. LPP is localized in cellular adhesion sites and is in certain conditions also detected in the nucleus where it acts as a transcriptional coactivator. It is highly expressed in smooth muscle cells and plays a role in cell migration. In particular tumors, aberrant LPP proteins are expressed in which the LIM domains are fused to DNA-binding domains. These tumor-specific LPP fusion proteins function as transcription factors.