Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Lipid Peroxidation

  • Aikaterini T. Vasilaki
  • Donald C. McMillan
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3373-2

Definition

Lipid peroxidation is the metabolic process in which reactive oxygen species (ROS) result in the oxidative deterioration of lipids. This may significantly affect cell membrane structure and function.

Characteristics

Lipid peroxidation most often affects polyunsaturated fatty acids, because they contain methylene -CH2- groups which contain hydrogen that is especially reactive with ROS. Increased ROS production occurs in inflammation, during radiation, or during metabolism of hormones, drugs, and environmental toxins. This can overwhelm endogenous protective antioxidantmechanisms and increase ROS-mediated damage to membrane structure and function. Such ROS reactions can also lead to protein damage, including DNA repair enzymes and polymerases, impairment, and production of aldehyde by-products such as malondialdehyde (MDA; β-hydroxy-acrolein) and 4-hydroxy-2-nonenal (HNE). MDA is formed during homolytic decomposition of lipid hydroperoxides that contain more than two double...

Keywords

Lipid Peroxidation Lipid Hydroperoxide Increase Reactive Oxygen Species Production High Reactive Oxygen Species Fatty Acid Radical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Blair IA (2001) Lipid hydroperoxide-mediated DNA damage. Exp Gerontol 36:1473–1481CrossRefPubMedGoogle Scholar
  2. Del Rio D, Stewart AJ, Pellegrini N (2005) A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316–328CrossRefPubMedGoogle Scholar
  3. Karihtala P, Soini Y (2007) Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies. APMIS 115:81–103CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.University Department of Surgery, Royal InfirmaryGlasgowUK