Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Lipid Mediators

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3372-3

Synonyms

Definition

Lipid mediators are bioactive molecules rapidly produced upon cell activation either by enzymatic process or by oxidative fragmentation of polyunsaturated fatty acids attached to their glycerol backbone. The majority of lipid mediators are products of degradation and/or phosphorylation/dephosphorylation of glycerophospholipids by defined enzymes acting in concert and commonly designated as phospholipases (PLs), phosphokinases, and phosphatases. Hydrolysis of phospholipids also generates free fatty acids, including arachidonate, a direct precursor of eicosanoids.

Characteristics

Within seconds after cell activation, certain phospholipids are either selectively hydrolyzed by defined phospholipases, leading to highly bioactive molecules (lipids and/or fatty acids), or phosphorylated by specific kinases to bioactive phosphoinositides, inositol lipids. Essentially, three phospholipase (PL) families, namely, phospholipase A2 (PLA2)...

Keywords

Conjugate Linoleic Acid Lipid Mediator Beta Carotene Inositol Trisphosphate Arachidonic Acid Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access

References

  1. Lee KW, Lee HJ, Cho HY et al (2005) Crit Rev Food Sci Nutr 45:135–144CrossRefPubMedGoogle Scholar
  2. Mills GB, Moolenaar WH (2003) Nat Rev Cancer 3:582–591CrossRefPubMedGoogle Scholar
  3. Rossi DJ, Weissman IL (2006) Cell 125:229–231CrossRefPubMedGoogle Scholar
  4. Segui B, Andrieu-Abadie N, Jaffrezou JP et al (2006) Biochim Biophys Acta 1758:2104–2120CrossRefPubMedGoogle Scholar
  5. Ulrich CM, Bigler J, Potter JD (2006) Nat Rev Cancer 6:130–140CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.INSERM UMRSUniversité Pierre et Marie Curie-ParisParisFrance