Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Antisense DNA Therapy

  • Bruno Calabretta
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_335-2

Definition

Antisense DNA therapy refers to the introduction of short antisense strands of DNA, which then bind with target mRNA. Many cancers are due to overexpression of the genes that promote cell proliferation, called tumor suppressor genes. Antisense RNA might be able to inhibit this overexpression. Antisense DNA is single-stranded DNA of various lengths that is complementary to the mRNA of a given gene. The antisense DNA binds to the mRNA and, by mechanisms that are not completely understood, inhibits its natural function, i.e., translation into protein. Antisense nucleic acids are widely used to study the effect of genes in cultured cells. The potential of antisense nucleic acids in gene therapy, for instance to therapeutically downregulate the expression of overexpressed genes, is being evaluated.

Characteristics

It is increasingly clear that the process of tumorigenesis is intimately associated with the accumulation of specific genetic abnormalities. This recognition has led to...

Keywords

Chronic Myeloid Leukemia Chronic Myelogenous Leukemia Autologous Bone Marrow Chronic Myelogenous Leukemia Patient Antileukemia Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Kimmel Cancer InstituteThomas Jefferson UniversityPhiladelphiaUSA