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Encyclopedia of Cancer pp 1–7Cite as

Lats

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Synonyms

kpm–mammalian LATS2; Large tumor suppressor; Warts (wts)–Drosophila lats; WARTS (WTS)–mammalian LATS1

Characteristics

How organisms regulate organ size and growth so that the size of various organs scale relative to the size of the whole body has fascinated scientists for centuries. In classic salamander limb transplantation experiments, Twitty and Schwind demonstrated that tissue contain intrinsic information that regulate their growth (Twitty and Schwind 1931). This notion was further established in Drosophila transplantation experiments where intact young wings or fragments of wing disks transplanted into the abdomen of an adult fly grew to reach normal size (Bryant and Levinson 1985; Worley et al. 2013). These studies suggested that tissues-intrinsic signals control growth, ultimately the organ size. In addition to these intrinsic cues, it is widely accepted that systemic or extrinsic cues such as insulin and growth factors also control growth. Starvation or genetic...

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See Also

  • (2012) Epithelial Cell. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1291–1292. doi:10.1007/978-3-642-16483-5_1958

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  • (2012) Imaginal Discs. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1808. doi:10.1007/978-3-642-16483-5_2962

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  • (2012) Mosaic. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2373. doi:10.1007/978-3-642-16483-5_3838

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT, USA

    Chiswili Chabu, Duc Nguyen & Tian Xu

  2. 454 Life Sciences, 15 Commercial Street, Branford, CT, 06405, USA

    Greg Turenchalkb

Authors
  1. Chiswili Chabu
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  2. Duc Nguyen
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  3. Greg Turenchalkb
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  4. Tian Xu
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Corresponding author

Correspondence to Tian Xu .

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Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Chabu, C., Nguyen, D., Turenchalkb, G., Xu, T. (2014). Lats. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3290-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_3290-2

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  • Online ISBN: 978-3-642-27841-9

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