Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Laminin Signaling

  • Reuven Reich
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3270-2

Definition

Laminins are a family of glycoproteins with an apparent molecular weight between 400 and 900 kDa. They are heterotrimers of three subunits, α, β, and γ, held together by disulfide bonds to form triple helical-coiled coil in a shape of a cross. Five α-chains, three β-chains, and three γ-chains have been identified, and by combination they assemble to form over 14 laminin isoforms that have different tissue distributions and functions. Laminins are essential for basement membrane assembly, promote cell attachment and angiogenesis, induce neurite outgrowth, affect gene expression, and are involved in cell proliferation, migration, and differentiation. Biochemical dissection related some of the laminin functions to specific parts of the glycoproteins. It appears that different parts in the molecules have different effects on cells. Some of these parts are cryptic and interact with cells only after proteolytic cleavage of the laminin molecules. In vitro, most structural and...

Keywords

Focal Adhesion Kinase Malignant Mesothelioma Laminin Receptor Laminin Isoforms Focal Adhesion Kinase Tyrosine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institute for Drug Research, School of Pharmacy, Faculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael