Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

KSP Mitotic Spindle Motor Protein

  • Weikang Tao
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3247-2

Synonyms

Definition

KSP mitotic spindle motor protein is a microtubule-associated molecular motor belonging to the kinesin superfamily, which plays an essential role in the separation of centrosomes, the assembly of bipolar spindles, and the faithful segregation of chromosomes into daughter cells during mitosis.

Characteristics

KSP is a plus-end-directed microtubule motor protein, well conserved from yeast to mammals. It can generate directed mechanical force by hydrolyzing ATP and move along microtubule filaments from the minus end (oriented towards the nucleus) to the plus end (oriented towards the cell periphery). The KSP protein contains a highly conserved N-terminal motor domain encompassing the head and neck motifs, a coiled-coil stalk domain, and a tail region containing a characteristic BimC box close to the C-terminus. Based on the N-terminal motor domain sequence, the vertebrate KSP belongs to the BimC...

Keywords

Mitotic Spindle Vinca Alkaloid Spindle Assembly Checkpoint Kinesin Spindle Protein Duplicate Centrosome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Cancer ResearchMerck Research LaboratoriesWest PointUSA