Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Kit/Stem Cell Factor Receptor in Oncogenesis

  • Peter Blume-Jensen
  • Tony Hunter
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3230-2

Synonyms

Definition

Kit/SCF-R is a receptor protein tyrosine kinase (RPTK) encoded by the proto-oncogene c-kit, which is allelic with the murine dominant white-spotting (W) locus on chromosome 5 and whose human homologue is located on human chromosome 4 (4 q11–12).

Characteristics

Going from the N terminus toward the C terminus, all RPTKs contain an extracellular ligand-binding domain, a single transmembrane-spanning domain, and an intracellular domain composed of a hydrophilic juxtamembrane (JM) region, followed by the highly conserved tyrosine kinase domain and a hydrophilic C terminus. Based on structural similarities, Kit/SCF-R belongs to the subclass III of RPTKs that includes the receptors for platelet-derived growth factor (PDGF) α and β, colony-stimulating factor-1 (CSF-1), and the Flt-3/Flk-2 RPTK. These proteins are ∼950–1100 amino acids in length, with ∼550...

Keywords

Mast Cell Acute Myeloid Leukemia Chronic Myeloid Leukemia Systemic Mastocytosis Acute Myeloid Leukemia Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Besmer P et al. (1993) The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl pp 125–137Google Scholar
  2. Blume-Jensen P, Hunter T (2001) Receptor tyrosine kinase-initiated signal transduction: mechanisms and specifity. In: Bertino JR (ed) Encyclopedia of cancer, vol 2, 2nd edn. Academic Press, San Diego, pp 213–234Google Scholar
  3. Galli SJ, Zsebo KM, Geissler EN (1994) The kit ligand, stem cell factor. Adv Immunol 55:1–96CrossRefPubMedGoogle Scholar
  4. Hanks SK, Hunter T (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 9:576–596PubMedGoogle Scholar
  5. Hubbard SR, Till JH (2000) Protein tyrosine kinase structure and function. Annu Rev Biochem 69:373–389CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Xtuit PharmaceuticalsBostonUSA
  2. 2.Salk InstituteMolecular and Cell Biology LaboratoryLa JollaUSA