Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Kit/Stem Cell Factor Receptor in Oncogenesis

  • Peter Blume-Jensen
  • Tony Hunter
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3230-2



Kit/SCF-R is a receptor protein tyrosine kinase (RPTK) encoded by the proto-oncogene c-kit, which is allelic with the murine dominant white-spotting (W) locus on chromosome 5 and whose human homologue is located on human chromosome 4 (4 q11–12).


Going from the N terminus toward the C terminus, all RPTKs contain an extracellular ligand-binding domain, a single transmembrane-spanning domain, and an intracellular domain composed of a hydrophilic juxtamembrane (JM) region, followed by the highly conserved tyrosine kinase domain and a hydrophilic C terminus. Based on structural similarities, Kit/SCF-R belongs to the subclass III of RPTKs that includes the receptors for platelet-derived growth factor (PDGF) α and β, colony-stimulating factor-1 (CSF-1), and the Flt-3/Flk-2 RPTK. These proteins are ∼950–1100 amino acids in length, with ∼550...


Mast Cell Acute Myeloid Leukemia Chronic Myeloid Leukemia Systemic Mastocytosis Acute Myeloid Leukemia Case 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Xtuit PharmaceuticalsBostonUSA
  2. 2.Salk InstituteMolecular and Cell Biology LaboratoryLa JollaUSA