Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

KISS1

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3227-2

Definition

KISS1 (GenBank Accession No. U43527) is a human metastasis-suppressor gene that was discovered in human melanoma cells. The name is derived from SS for putative Suppressor Sequence; the Ki was added to remind people of its discovery in Hershey, Pennsylvania. Upon introduction into metastatic cells, which normally do not express the gene, the cells retain the ability to form tumors while losing their ability to metastasize.

Although this entry focuses on the roles of KISS1 in cancer metastasis (as KISS1 was originally discovered) the physiologic role of KISS1 is as a neurotransmitter which binds to a G-protein coupled receptor (KISS1R) to regulate the hypothalamic-pituitary-gonadal axis. Readers are encouraged to read any of several excellent reviews on the topic of its endocrine functions.

Characteristics

As melanomas progress toward increasing malignancy, nonrandom chromosomal and metabolic changes occur to facilitate a metastasis. Deletion of chromosome 6 tends to occur at...

Keywords

Human Melanoma Cell Disseminate Tumor Cell Metastasis Suppressor Metastasis Suppressor Gene GnRH Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Beck BH, Welch DR (2010) The KISS1 metastasis suppressor: a good night KISS for disseminated cancer cells. Eur J Cancer 46(7):1283–1289CrossRefPubMedPubMedCentralGoogle Scholar
  2. Lee JH, Miele ME, Hicks DJ et al (1996) KISS-1, a novel malignant melanoma metastasissuppressor genes identified in chromosome 6-malignant melanoma microcell hybrids. J Natl Cancer Inst 88:1731–1737CrossRefPubMedGoogle Scholar
  3. Liu W, Beck BH, Vaidya KS, Nash KT et al (2014) Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis. Cancer Res 74(3):954–963, s12307-014-0148-4CrossRefPubMedGoogle Scholar
  4. Nash KT, Phadke PA, Navenot J-M et al (2007) KISS1 metastasis suppressor secretion is required for multiple organ metastasis suppression and for the maintenance of disseminated cells in a dormant state. J Natl Cancer Inst 99:309–321CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Cancer BiologyKansas University Cancer CenterKansas CityUSA
  2. 2.The University of Kansas Medical CenterKansas CityUSA