Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Konan Peck
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3194-2



Kallikreins are a family of serine proteases encoded by genes clustered on chromosome 19q13.4. Their expression is associated with progression of several cancers, and they serve as biomarkers. Among the kallikreins, prostate-specific antigen (PSA; kallikrein 3, KLK3) is the most well-known kallikrein.


Kallikreins play important roles in cancer development. For several decades, kallikreins have been known as enzymes that generate bioactive peptides, called kinins, involved in blood-pressure regulation. When the first kallikrein (kallikrein 1) was discovered in 1930, the enzyme was reported to have a hypotensive effect and be present at high concentrations in the pancreas, the organ known as kallikreasin Greek. It is now known that kallikrein 1 produces bradykinin from kininogen. Bradykinin is an active peptide of the kinin protein group. It consists of nine amino acid residues and is a potent...


Catalytic Triad Urokinase Plasminogen Activator Tissue Kallikrein Plasma Kallikrein Endometrial Cancer Cell Line 
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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute of Biomedical SciencesAcademia Sinica TaipeiTaiwanRepublic of China