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IQGAP1 Protein

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Encyclopedia of Cancer

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Synonyms

IQ motif-containing GTPase-activating protein

Definition

IQGAP1 is the best-characterized member of the IQGAP family of eukaryotic proteins that were first identified in 1994 in metastatic human osteosarcoma cells. This family of proteins is found in a wide spectrum of species and is highly conserved throughout the evolution from yeast to human. The name refers to the presence of “IQ” motifs and a domain similar to Ras GTPase-activating proteins (GAP).

Characteristics

IQGAP1 is a member of IQGAP family that has been characterized in yeast, Hydra, worms, and mammals. The human IQGAP1 isoform is most similar to mouse IQGAP1 (94 % identity) and has 62 % identity to human IQGAP2. IQGAP1 is the prototype of this family and the most extensively studied member. IQGAP1 is a multimodular scaffolding protein that binds to a diverse array of signaling and structural molecules which confers it many different roles in cell physiology. IQGAP1 domains and target proteins are presented in...

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References

  • Balenci L, Clarke ID, Dirks PB et al (2006) IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme. Cancer Res 66:9074–9082

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  • Brown MD, Sacks DB (2006) IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol 16:242–249

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  • Li S, Wang Q, Chakladar A et al (2000) Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1. Mol Cell Biol 20:697–701

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  • Noritake J, Watanabe T, Sato K et al (2005) IQGAP1: a key regulator of adhesion and migration. J Cell Sci 118:2085–2092

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  • Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L et al (2004) IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation. Circ Res 95:276–283

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. INSERM Unité Mixte 873, Grenoble, Cedex 09, France

    Laurent Balenci & Jacques Baudier

Authors
  1. Laurent Balenci
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  2. Jacques Baudier
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Corresponding author

Correspondence to Laurent Balenci .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Balenci, L., Baudier, J. (2015). IQGAP1 Protein. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3144-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_3144-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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