Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

IQGAP1 Protein

  • Laurent Balenci
  • Jacques Baudier
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3144-2



IQGAP1 is the best-characterized member of the IQGAP family of eukaryotic proteins that were first identified in 1994 in metastatic human osteosarcoma cells. This family of proteins is found in a wide spectrum of species and is highly conserved throughout the evolution from yeast to human. The name refers to the presence of “IQ” motifs and a domain similar to Ras GTPase-activating proteins (GAP).


IQGAP1 is a member of IQGAP family that has been characterized in yeast, Hydra, worms, and mammals. The human IQGAP1 isoform is most similar to mouse IQGAP1 (94 % identity) and has 62 % identity to human IQGAP2. IQGAP1 is the prototype of this family and the most extensively studied member. IQGAP1 is a multimodular scaffolding protein that binds to a diverse array of signaling and structural molecules which confers it many different roles in cell physiology. IQGAP1 domains and target proteins are presented in...


Poly Proline Calponin Homology Domain Common Primary Brain Tumor Intrinsic GTPase Activity Express Stem Cell Marker 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.INSERM Unité Mixte 873GrenobleFrance