Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

IQGAP1 Protein

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3144-2

Synonyms

Definition

IQGAP1 is the best-characterized member of the IQGAP family of eukaryotic proteins that were first identified in 1994 in metastatic human osteosarcoma cells. This family of proteins is found in a wide spectrum of species and is highly conserved throughout the evolution from yeast to human. The name refers to the presence of “IQ” motifs and a domain similar to Ras GTPase-activating proteins (GAP).

Characteristics

IQGAP1 is a member of IQGAP family that has been characterized in yeast, Hydra, worms, and mammals. The human IQGAP1 isoform is most similar to mouse IQGAP1 (94 % identity) and has 62 % identity to human IQGAP2. IQGAP1 is the prototype of this family and the most extensively studied member. IQGAP1 is a multimodular scaffolding protein that binds to a diverse array of signaling and structural molecules which confers it many different roles in cell physiology. IQGAP1 domains and target proteins are presented in...

Keywords

Poly Proline Calponin Homology Domain Common Primary Brain Tumor Intrinsic GTPase Activity Express Stem Cell Marker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access

References

  1. Balenci L, Clarke ID, Dirks PB et al (2006) IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme. Cancer Res 66:9074–9082CrossRefPubMedGoogle Scholar
  2. Brown MD, Sacks DB (2006) IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol 16:242–249CrossRefPubMedGoogle Scholar
  3. Li S, Wang Q, Chakladar A et al (2000) Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1. Mol Cell Biol 20:697–701CrossRefPubMedPubMedCentralGoogle Scholar
  4. Noritake J, Watanabe T, Sato K et al (2005) IQGAP1: a key regulator of adhesion and migration. J Cell Sci 118:2085–2092CrossRefPubMedGoogle Scholar
  5. Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L et al (2004) IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation. Circ Res 95:276–283CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.INSERM Unité Mixte 873GrenobleFrance