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Antibody-Dependent Cellular Cytotoxicity

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Encyclopedia of Cancer

  • 143 Accesses

Definition

ADCC is a passive immune response in which the Fc fragment of a (therapeutic) monoclonal antibody binds or ligates activating immunoglobulin Fc receptors, e.g., Fc RI (CD64), Fc RIIa (CD32a), Fc RIIc (CD32c), or Fc RIII (CD16), present on monocytes, macrophages, granulocytes, and natural killer (NK) cells, driving cytotoxic effector functions to target membrane-associated antigens.

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Authors and Affiliations

  1. German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Manfred Schwab

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  1. Manfred Schwab
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Correspondence to Manfred Schwab .

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  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Schwab, M. (2015). Antibody-Dependent Cellular Cytotoxicity. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_313-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_313-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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