Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Interleukin-6

  • Taosheng Chen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3099-3

Synonyms

Definition

IL-6 is a member of a family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), IL-11, and cardiotrophin-1 (CT-1). These cytokines are functionally redundant and structurally similar. They also share receptor subunit for signal transduction and thus elicit similar and overlapping physiological responses. IL-6 is a multifunctional cytokine. In addition to its important roles in the immune response, inflammation, and hematopoiesis, IL-6 is also involved in other important physiological processes such as promotion of osteoclast resorption of bone and regulation of the growth of many tumor cells.

Characteristics

The human IL-6 gene was cloned in 1986. It contains five exons in its 5 kb genomic DNA, which is mapped to human chromosome 7p21–p14. IL-6 is first synthesized as a precursor protein...

Keywords

Prostate Cancer Androgen Receptor Leukemia Inhibitory Factor Human Lung Cancer Cell Line Important Physiological Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Chen T, Cho RW, Stork PJS et al (1999) Elevation of cyclic adenosine 3′,5′-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells. Cancer Res 59:213–218PubMedGoogle Scholar
  2. Chen T, Wang L-H, Farrar WL (2000) Interleukin-6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells. Cancer Res 60:2132–2135PubMedGoogle Scholar
  3. Hirano T (1998) Interleukin-6 and its receptor: ten years later. Intern Rev Immunol 16:249–284CrossRefGoogle Scholar

See Also

  1. (2012) Autoimmune diseases. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 311. doi: 10.1007/978-3-642-16483-5_473Google Scholar
  2. (2012) Endothelial cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1251. doi: 10.1007/978-3-642-16483-5_1896Google Scholar
  3. (2012) Estrogens. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1333. doi: 10.1007/978-3-642-16483-5_2019Google Scholar
  4. (2012) Fibroblasts. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1398. doi: 10.1007/978-3-642-16483-5_2176Google Scholar
  5. (2012) Glucocorticoids. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1558. doi: 10.1007/978-3-642-16483-5_2429Google Scholar
  6. (2012) Interleukin-1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1892. doi: 10.1007/978-3-642-16483-5_3095Google Scholar
  7. (2012) JAK. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1923. doi: 10.1007/978-3-642-16483-5_3170Google Scholar
  8. (2012) Lymphoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2124. doi: 10.1007/978-3-642-16483-5_3463Google Scholar
  9. (2012) Monocyte. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2371. doi: 10.1007/978-3-642-16483-5_3825Google Scholar
  10. (2012) Posttranslational modification. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2966. doi: 10.1007/978-3-642-16483-5_4696Google Scholar
  11. (2012) Renal-cell carcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3252. doi: 10.1007/978-3-642-16483-5_5023Google Scholar
  12. (2012) STAT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3502. doi: 10.1007/978-3-642-16483-5_5481Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Chemical Biology and TherapeuticsSt. Jude Children’s Research HospitalMemphisUSA