Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Integrin Signaling

  • Michael Z. Gilcrease
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3087-2

Definition

Integrins comprise a family of cell surface receptors that bind extracellular matrix proteins and cell surface counterreceptors, thereby linking the cell’s microenvironment to the cytoskeleton.

Characteristics

Virtually all cells of multicellular animals express integrins, and most cells of adult mammals constitutively express multiple different integrins. These cell surface receptors play an important role in mediating cell adhesionto adjacent connective tissue proteins. Integrins are transmembrane heterodimers that consist of noncovalently bound glycoprotein subunits. Each heterodimer is composed of a single α- and a single β-subunit, both of which participate in ligand recognition. A total of 18 α- and β-subunits have been identified, some of which have multiple splice variants, and these combine to form 24 distinct integrin heterodimers. Most integrins (with the notable exception of α6β4) have small cytoplasmic domains that are connected to the cytoskeleton by multiple...

Keywords

Focal Adhesion Kinase Integrin Signaling Malignant Epithelial Cell Integrin Heterodimers Integrin Ligation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Gilcrease MZ (2007) Integrin signaling in epithelial cells. Cancer Lett 247:1–25CrossRefPubMedGoogle Scholar
  2. Guo W, Giancotti FG (2004) Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5:816–826CrossRefPubMedGoogle Scholar
  3. Hood JD, Cheresh DA (2002) Role of integrins in cell invasion and migration. Nat Rev Cancer 2:91–100CrossRefPubMedGoogle Scholar
  4. Miranti CK, Brugge JS (2002) Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol 4:E83–E90CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Pathology, Breast SectionM. D. Anderson Cancer CenterHoustonUSA