Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Insulinoma

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3081-2

Synonyms

Definition

Insulinomas are functioning insulin-producing tumors of the pancreatic islets of Langerhans, resulting in hypoglycemia.

Characteristics

Insulinomas arise from the β-cell of the pancreatic islets. The nonregulated secretion of insulin from these tumor cells into the blood stream results in fasting hypoglycemia. Insulinomas are relatively rare, with approximately four cases per million person-years. However, they are the most common tumor of the pancreatic islets. Insulinomas may appear at any age, but the majority appears in the fifth decade. Insulinomas are evenly distributed along the pancreas. Insulinomas, associated with multiple endocrine neoplasia type 1 (MEN1), tend to appear one decade earlier. Insulinomas are usually solitary and their localization is even along the pancreas, exceptions are those associated with MEN1, where multiple tumors are the rule.

Diagnosis

The presence of Whipple Triad (hypoglycemia and neuroglycopenic...

Keywords

Pancreatic Islet Pancreatic Endocrine Tumor Proinsulin Level Malignant Insulinoma Fasting Hypoglycemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Hirshberg B, Livi A, Bartlett DL et al (2000) Forty-eight-hour fast: the diagnostic test for insulinoma. J Clin Endocrinol Metab 85(9):3222–3226CrossRefPubMedGoogle Scholar
  2. Hirshberg B, Libutti SK, Alexander HR et al (2002) Blind distal pancreatectomy for occult insulinoma, an inadvisable procedure. J Am Coll Surg 194(6):761–764CrossRefPubMedGoogle Scholar
  3. Hirshberg B, Cochran C, Skarulis MC et al (2005) Malignant insulinoma: spectrum of unusual clinical features. Cancer 104(2):264–272CrossRefPubMedPubMedCentralGoogle Scholar
  4. Service FJ, McMahon MM, O’Brien PC et al (1991) Functioning insulinoma – incidence, recurrence, and long-term survival of patients: a 60-year study. Mayo Clin Proc 66(7):711–719CrossRefPubMedGoogle Scholar
  5. Skarulis MC, Hirshberg B (2004) Hypoglycemia in the adult. In: LeRoith D, Taylor SI, Olefsky JM (eds) Diabetes mellitus: a fundamental and clinical text, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 1427–1440Google Scholar

See Also

  1. (2012) Computed Tomography. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 964–965. doi: 10.1007/978-3-642-16483-5_1295Google Scholar
  2. (2012) Embolization. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1220. doi: 10.1007/978-3-642-16483-5_1856Google Scholar
  3. (2012) Insulin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1873–1874. doi: 10.1007/978-3-642-16483-5_3075Google Scholar
  4. (2012) Islets of Langerhans. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1917. doi: 10.1007/978-3-642-16483-5_3154Google Scholar
  5. (2012) Magnetic Resonance Imaging. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2136. doi: 10.1007/978-3-642-16483-5_3496Google Scholar
  6. (2012) Tolbutamide Intravenous Test. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3722. doi: 10.1007/978-3-642-16483-5_5852Google Scholar
  7. (2012) Whipple Triad. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3945. doi: 10.1007/978-3-642-16483-5_6242Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Cardiovascular and Metabolic Diseases, Pfizer IncGrotonUSA