Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Insulin-Like Growth Factors

  • Ruslan Novosiadly
  • Derek LeRoith
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3080-3

Definition

The insulin-like growth factors (IGF-I and IGF-II) are structurally related molecules that play essential roles in the regulation of cell survival, growth, proliferation, differentiation, and metabolism. The IGF family is comprised of (i) ligands (IGF-I, IGF-II, and insulin), (ii) six well-characterized high-affinity binding proteins (IGFBP-1−6), (iii) IGFBP proteases, and (iv) cell surface receptors that mediate the biological functions of IGFs. These transmembrane receptors include the IGF-I receptor (IGF-IR), IGF-II/mannose 6-phosphate receptor (IGF-II/M6PR), insulin receptor (IR), and insulin receptor-related receptor (IRR). In many tumor cells, the IGF-IR is often upregulated and/or hyperactivated. Furthermore, increased circulating IGF-I levels are considered a significant risk factor for the development of various types of cancers. Although the oncogenic role of IGFs (i.e., their ability to initiate carcinogenesis) is still under the debate, numerous lines of...

Keywords

Bivalent Ligand IGFBP Protease GHRH Antagonist Enhance Cell Cycle Progression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

  1. (2012) AKT. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 115. doi: 10.1007/978-3-642-16483-5_163Google Scholar
  2. (2012) Dominant Negative. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1150. doi: 10.1007/978-3-642-16483-5_1705Google Scholar
  3. (2012) MAPK. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2167. doi: 10.1007/978-3-642-16483-5_3532Google Scholar
  4. (2012) Mitogen-Activated Protein Kinase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2336. doi: 10.1007/978-3-642-16483-5_3770Google Scholar
  5. (2012) Monoclonal Antibody. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2367. doi: 10.1007/978-3-642-16483-5_6842Google Scholar
  6. (2012) P53. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331Google Scholar
  7. (2012) Palliative. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2759. doi: 10.1007/978-3-642-16483-5_4350Google Scholar
  8. (2012) Radiation Therapy. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3144. doi: 10.1007/978-3-642-16483-5_4907Google Scholar
  9. (2012) Shc. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3401. doi: 10.1007/978-3-642-16483-5_5284Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Cancer ImmunobiologyEli Lilly and CompanyNew YorkUSA
  2. 2.Division of Endocrinology, Diabetes and Bone DiseasesMount Sinai School of MedicineNew YorkUSA