Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Inositol Lipids

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3068-2

Definition

Are a class of phospholipids where inositol is the polar headgroup. The simplest inositol phospholipid is phosphatidylinositol (PtdIns). The inositol moiety can be phosphorylated at several different positions giving rise to a number of other molecular species.

Characteristics

Among different inositol lipids, the importance in transmembrane signaling and regulation of cell functions are best documented for PtdIns(4,5)P2 and PtdIns(3,4,5)P3. There are several ways in which these low-abundance inositol lipids (less than 1 % of membrane phospholipids) could provide a signaling link or fulfill other roles in different cellular processes.

Hydrolysis of PtdIns(4,5)P2 to Generate Second Messenger Molecules

Hydrolysis of PtdIns(4,5)P2 occurs in response to a large number of extracellular signals and generates two second messenger molecules, inositol (1,4,5) trisphosphate (Ins(1,4,5)P3) and diacylglycerol (DAG) molecules. The reaction is catalyzed by phosphoinositide-specific...

Keywords

PTEN Gene Pleckstrin Homology Domain Messenger Molecule Polar Headgroup Inositol Lipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

  1. (2012) Hemangiosarcoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1640. doi:10.1007/978-3-642-16483-5_2614Google Scholar
  2. (2012) Isoform. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 1920–1921. doi:10.1007/978-3-642-16483-5_3158Google Scholar
  3. (2012) Phosphatidyl inositol 3-kinase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2865. doi:10.1007/978-3-642-16483-5_4527Google Scholar
  4. (2012) Phospholipids. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2869–2870. doi:10.1007/978-3-642-16483-5_4542Google Scholar
  5. (2012) Phospholipase C. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2869. doi:10.1007/978-3-642-16483-5_4539Google Scholar
  6. (2012) Pleckstrin homology domains. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2919. doi:10.1007/978-3-642-16483-5_4620Google Scholar
  7. (2012) Posttranslational modification. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2966. doi:10.1007/978-3-642-16483-5_4696Google Scholar
  8. (2012) Retrovirus. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3296–3297. doi:10.1007/978-3-642-16483-5_5084Google Scholar
  9. (2012) Second messenger. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3343. doi:10.1007/978-3-642-16483-5_5192Google Scholar
  10. (2012) Signal-transducer proteins. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3411. doi:10.1007/978-3-642-16483-5_5299Google Scholar
  11. (2012) Transmembrane signaling. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3774. doi:10.1007/978-3-642-16483-5_5952Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.CRC Centre for Cell and Molecular BiologyInstitute of Cancer ResearchLondonUK