Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Innate Immunity

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3064-6

Synonyms

Definition

Innate immunity represents the first line of defense against a wide range of pathogens or damage signals and plays key roles in generating a protective inflammatory response as well as activating and instructing the adaptive immune response. It is present at birth and can pass down genetically from parents to children.

Characteristics

Previously, innate immunity was characterized by a rapid, nonspecific immune response to pathogens. However, recent studies demonstrate that innate immune responses show a greater degree of specificity to discriminate self from pathogens than previously appreciated. Furthermore, innate immunity is the master regulator of all immune responses and plays a key role in the activation of adaptive immunity. As the first line of defense, the innate immune system has three main components to allow for rapid and efficient removal of invading pathogens: barriers and cellular and humoral effector components.

Barriers

When...

Keywords

Innate Immunity Innate Immune Response Adaptive Immunity Innate Immune Cell Complement Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Beutler B (2004) Innate immunity: an overview. Mol Immunol 40:845–859CrossRefPubMedGoogle Scholar
  2. Imler JL, Hoffmann JA (2000) Toll and Toll-like proteins: an ancient family of receptors signaling infection. Rev Immunogenet 2:294–304PubMedGoogle Scholar
  3. Janeway CA Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197–216CrossRefPubMedGoogle Scholar
  4. Schenten D, Medzhitov R (2011) The control of adaptive immune responses by the innate immune system. Adv Immunol 109:87–124CrossRefPubMedGoogle Scholar
  5. Steinman RM (2006) Linking innate to adaptive immunity through dendritic cells. Novartis Found Symp 279:101–109; discussion 109–113, 216–219CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of ImmunologySt. Jude Children’s Research HospitalMemphisUSA