Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Inflammatory Bowel Disease-Associated Cancer

  • Jean-Marie REIMUND
  • Jean-Noël FREUND
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3046-2


Concepts for inflammatory bowel diseases (IBDs) pathogenesis have evolved in recent years suggesting that they result from an altered intestinal mucosal inflammatory/immune response to the digestive commensal microbiota in patients having a genetic predisposition conferring risk of disease. Two major forms of IBD, ulcerative colitis (UC) and Crohn disease (CD), have been described. Ulcerative colitis is characterized by a diffuse but usually superficial inflammation of the colonic mucosa, affecting the rectum and extending proximally along a variable length of the colon. Crohn disease is a chronic granulomatous inflammation which may affect the entire gastrointestinal tract with predominant locations at the terminal ileum and/or colon. By contrast to UC, inflammatory lesions in CD patients are often distributed heterogeneously as a patchwork of inflamed and noninflamed fields of intestinal mucosa.

Both UC and CD patients are at higher risk of cancer development, in...


Ulcerative Colitis Familial Adenomatous Polyposis Lynch Syndrome Primary Sclerosing Cholangitis Ulcerative Colitis Patient 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Université de Strasbourg, Faculté de Médecine, INSERM U1113 and Fédération de Médecine Translationnelle de Strasbourg (FMTS), and, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Service d’Hépato-Gastroentérologie et d’Assistance NutritiveStrasbourgFrance
  2. 2.INSERM U1113 and Fédération de Médecine Translationnelle de Strasbourg (FMTS)Université de Strasbourg, Faculté de MédecineStrasbourgFrance