Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Inflammatory Bowel Disease-Associated Cancer

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3046-2

Definition

Concepts for inflammatory bowel diseases (IBDs) pathogenesis have evolved in recent years suggesting that they result from an altered intestinal mucosal inflammatory/immune response to the digestive commensal microbiota in patients having a genetic predisposition conferring risk of disease. Two major forms of IBD, ulcerative colitis (UC) and Crohn disease (CD), have been described. Ulcerative colitis is characterized by a diffuse but usually superficial inflammation of the colonic mucosa, affecting the rectum and extending proximally along a variable length of the colon. Crohn disease is a chronic granulomatous inflammation which may affect the entire gastrointestinal tract with predominant locations at the terminal ileum and/or colon. By contrast to UC, inflammatory lesions in CD patients are often distributed heterogeneously as a patchwork of inflamed and noninflamed fields of intestinal mucosa.

Both UC and CD patients are at higher risk of cancer development, in...

Keywords

Ulcerative Colitis Familial Adenomatous Polyposis Lynch Syndrome Primary Sclerosing Cholangitis Ulcerative Colitis Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Barral M, Dohan A, Allez M, Boudiaf M, Camus M, Laurent V, Hoeffel C, Soyer P (2016) Gastrointestinal cancers in inflammatory bowel disease: an update with emphasis on imaging findings. Crit Rev Oncol Hematol 97:30–46Google Scholar
  2. Beaugerie L and Itzkowitz SH (2015) Cancers complicating inflammatory bowel disease. N Engl J Med 372:1441–1452Google Scholar
  3. Elris K, Carrat F, Carbonnel F, Marthey L, Bouvier AM, Beaugerie L (2013) Incidence, presentation, and prognosis of small bowel adenocarcinoma in patients with small bowel Crohn’s disease: a prospective observational study. Inflamm Bowel Dis 19:1823–1826Google Scholar
  4. Farraye FA (ed) (2006) Dysplasia and cancer in inflammatory bowel disease. Gastroenterol Clin North Am 35:517–734Google Scholar
  5. Itzkowitz SH, Yio X (2004) Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 287:G7–G17CrossRefPubMedGoogle Scholar
  6. Kwon JH, Farrell RJ (2005) The risk of lymphoma in the treatment of inflammatory bowel disease with immunosuppressive agents. Crit Rev Oncol Hematol 56:169–178CrossRefPubMedGoogle Scholar
  7. Li HC, Stoicov C, Rogers AB et al (2006) Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol 12:363–371CrossRefPubMedPubMedCentralGoogle Scholar
  8. Palascak-Juif V, Bouvier AM, Cosnes J et al (2005) Small bowel adenocarcinoma in patients with Crohn’s disease compared with small bowel adenocarcinoma de novo. Inflamm Bowel Dis 11:828–832CrossRefPubMedGoogle Scholar
  9. Viennot S, Deleporte A, Moussata D, Nancey S, Flourié B, Reimund JM (2009) Colon cancer in inflammatory bowel disease: recent trends, questions and answers. Gastroenterol Clin Biol 33 (Suppl. 3):S190–S201Google Scholar
  10. Zaho LN, Li JY, Yu T, Chen GC, Yuan YH, Chen QK (2014) 5-aminosalicylates reduce the risk of colorectal neoplasia in patients with ulcerative colitis: an updated meta-analysis. PLoS ONE 9:e94208Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Université de Strasbourg, Faculté de Médecine, INSERM U1113 and Fédération de Médecine Translationnelle de Strasbourg (FMTS), and, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Service d’Hépato-Gastroentérologie et d’Assistance NutritiveStrasbourgFrance
  2. 2.INSERM U1113 and Fédération de Médecine Translationnelle de Strasbourg (FMTS)Université de Strasbourg, Faculté de MédecineStrasbourgFrance