Inflammatory Bowel Disease-Associated Cancer
Concepts for inflammatory bowel diseases (IBDs) pathogenesis have evolved in recent years suggesting that they result from an altered intestinal mucosal inflammatory/immune response to the digestive commensal microbiota in patients having a genetic predisposition conferring risk of disease. Two major forms of IBD, ulcerative colitis (UC) and Crohn disease (CD), have been described. Ulcerative colitis is characterized by a diffuse but usually superficial inflammation of the colonic mucosa, affecting the rectum and extending proximally along a variable length of the colon. Crohn disease is a chronic granulomatous inflammation which may affect the entire gastrointestinal tract with predominant locations at the terminal ileum and/or colon. By contrast to UC, inflammatory lesions in CD patients are often distributed heterogeneously as a patchwork of inflamed and noninflamed fields of intestinal mucosa.
Both UC and CD patients are at higher risk of cancer development, in...
KeywordsUlcerative Colitis Familial Adenomatous Polyposis Lynch Syndrome Primary Sclerosing Cholangitis Ulcerative Colitis Patient
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