Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Inflammation

  • Lorne J. Hofseth
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3044-2

Definition

Inflammation is an immune response to infection or irritation. Inflammation is characterized by the following quintet: redness (rubor), heat (calor), swelling (tumor), pain (dolor), and dysfunction of the organs involved (functio laesa). Acute inflammation is short lasting, lasting only a few days. If it is longer lasting however, then it is referred to as chronic inflammation. Chronic inflammation is a prolonged inflammatory response (weeks, months, or even indefinitely). It is prolonged by the persistence of the causative stimulus to inflammation in the tissue. The inflammatory process unavoidably causes tissue damage and is accompanied by concurrent healing and repair.

Characteristics

Overall, chronic inflammation is bad for human health. There is a close association between chronic inflammation and prevalent diseases found in the developed world (cardiovascular disease/CVD, cancer, diabetes, and Alzheimer disease/AD to name a few). Evidence for this comes from...

Keywords

Inflammatory Bowel Disease Ulcerative Colitis Chronic Inflammation Reactive Nitrogen Species Crohn Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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See Also

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Pharmaceutical and Biomedical Sciences, South Carolina College of PharmacyUniversity of South CarolinaColumbiaUSA