Indirubin and Indirubin Derivatives
Living reference work entry
Indirubin is the parent compound of a spectrum of 2′,3-bisindoles synthesized to improve the biological activity of this natural 2′,3-bisindole lead structure. Indirubin and its isomers indigo and isoindigo are composed of two indolinone ring systems, linked through a double bond to make up 2,2′-(indigo), 3,2′-(indirubin) and 3,3′ (isoindigo) bisindoles, respectively (Fig. 1).
KeywordsChinese Scientist Inhibit Receptor Tyrosine Kinase Kinase Inhibitory Activity Traditional Chinese Medication Natural Indigo
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- Merz K-H, Eisenbrand G (2006) Chemistry and structure-activity of indirubins. In: Meijer L, Guyard N, Skaltsounis LA, Eisenbrand G (eds) Indirubin, the red shade of indigo. Editions “Life in Progress”, Roscoff, pp 135–145Google Scholar
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