Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Indirubin and Indirubin Derivatives

  • Gerhard Eisenbrand
  • Karl-Heinz Merz
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3032-2



Indirubin is the parent compound of a spectrum of 2′,3-bisindoles synthesized to improve the biological activity of this natural 2′,3-bisindole lead structure. Indirubin and its isomers indigo and isoindigo are composed of two indolinone ring systems, linked through a double bond to make up 2,2′-(indigo), 3,2′-(indirubin) and 3,3′ (isoindigo) bisindoles, respectively (Fig. 1).


Chinese Scientist Inhibit Receptor Tyrosine Kinase Kinase Inhibitory Activity Traditional Chinese Medication Natural Indigo 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Chemistry, Division of Food Chemistry and ToxicologyUniversity of KaiserslauternKaiserslauternGermany