Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Imprinting

  • Christoph Plass
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3019-2

Definition

Genomic imprinting describes a phenomenon in which a gene is expressed either from the paternal or from the maternal allele and thus discriminates these genes from the majority of genes that are expressed from both alleles.

Characteristics

Normally, genes are expressed from both the maternal and the paternal allele. Genomic imprinting results in allele-specific expression of certain genes from either the paternal or the maternal allele. These genes are marked before fertilization in a way that either the maternal or the paternal allele is transcriptionally silenced in the offspring. One of the first indications that certain autosomal regions are subject to genomic imprinting came from mouse genetic studies using Robertsonian and reciprocal translocations. In these studies, uniparental duplications or deficiencies for certain chromosomal regions were analyzed. The failure of a disomy or duplication from one parent to complement a corresponding nullisomy or deficiency from the...

Keywords

Imprint Gene Adrenocortical Carcinoma Angelman Syndrome Paternal Allele Maternal Allele 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bartolomei MS, Tilghman SM (1997) Genomic imprinting in mammals. Annu Rev Genet 31:493–525CrossRefPubMedGoogle Scholar
  2. Cattanach BM, Kirk M (1985) Differential activity of maternally and paternally derived chromosome regions in mice. Nature 315:496–498CrossRefPubMedGoogle Scholar
  3. Falls JG, Pulford DJ, Wylie AA et al (1999) Genomic imprinting: implications for human disease. Am J Pathol 154:635–647CrossRefPubMedPubMedCentralGoogle Scholar
  4. Nicholls RD, Saitoh S, Horsthemke B (1998) Imprinting in Prader–Willi and Angelman syndromes. Trends Genet 14:194–200CrossRefPubMedGoogle Scholar
  5. Reik W, Maher ER (1997) Imprinting in clusters: lessons from Beckwith–Wiedemann syndrome. Trends Genet 13:330–334CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany