Definition
Idiotype vaccination is an immunotherapy procedure based on the fact that, save for its very early stage of differentiation, each clone of B lymphocytes features a specific antibody on the cell surface. The most variable portion of this antibody is a unique feature of the corresponding clone. Its natural function is that of specifically recognizing an antigen, but it can also be used as an antigen (idiotype) itself, that is, as a potential vaccine target and tool. The most relevant context in which this second function is exploited is idiotype vaccination as a treatment for human B cell lymphoma.
Characteristics
Field of Application
The vast majority of B cell lymphomas consist of the clonal expansion of neoplastic B cells, all featuring the same surface antibody and consequently the same idiotype. However, each patient’s tumor presents with a different, patient-, and tumor-specific idiotype. Therefore, an...
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References
Bendandi M (2006) Clinical benefit of idiotype vaccines: too many trials for a clever demonstration? Rev Recent Clin Trials 1:67–74
Bendandi M (2009) Idiotype vaccines for lymphoma: proof-of-principles and clinical trial failures. Nat Rev Cancer 9:675–681
Bendandi M, Gocke CD, Kobrin CB et al (1999) Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma. Nat Med 5:1171–1177
de Cerio AL, Inogés S, Ai WZ, Villanueva H, Pastor F, Soldevilla MM, Soria E, Bendandi M (2013) Successful idiotypic vaccination following stem cell allotransplant in lymphoma. Leuk Lymphoma 54:881–884
Inogés S, Rodríguez-Calvillo M, Zabalegui N et al (2006) Clinical benefit associated with idiotypic vaccination in follicular lymphoma. J Natl Cancer Inst 98:1292–1301
Inoges S, de Cerio AL, Villanueva H, Pastor F, Bendandi M (2014) Idiotype vaccine production using hybridoma technology. Methods Mol Biol 1139:367–387
Kwak LW, Campbell MJ, Czerwinski DK et al (1992) Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N Engl J Med 327:1209–1215
See Also
(2012) Hematopoietic stem cell. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1645. doi:10.1007/978-3-642-16483-5_2619
(2012) Hybridomas. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1775. doi:10.1007/978-3-642-16483-5_2884
(2012) Idiotype. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1804. doi:10.1007/978-3-642-16483-5_2944
(2012) Monoclonal antibody. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2367. doi:10.1007/978-3-642-16483-5_6842
(2012) Radioimmunoconjugates. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3148. doi:10.1007/978-3-642-16483-5_4917
(2012) Recombinant. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3205. doi:10.1007/978-3-642-16483-5_4991
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Bendandi, M. (2014). Idiotype Vaccination. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_2945-5
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DOI: https://doi.org/10.1007/978-3-642-27841-9_2945-5
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