Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Idiotype Vaccination

  • Maurizio Bendandi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2945-5

Synonyms

Definition

Idiotype vaccination is an immunotherapy procedure based on the fact that, save for its very early stage of differentiation, each clone of B lymphocytes features a specific antibody on the cell surface. The most variable portion of this antibody is a unique feature of the corresponding clone. Its natural function is that of specifically recognizing an antigen, but it can also be used as an antigen (idiotype) itself, that is, as a potential vaccine target and tool. The most relevant context in which this second function is exploited is idiotype vaccination as a treatment for human B cell lymphoma.

Characteristics

Field of Application

The vast majority of B cell lymphomas consist of the clonal expansion of neoplastic B cells, all featuring the same surface antibody and consequently the same idiotype. However, each patient’s tumor presents with a different, patient-, and tumor-specific idiotype. Therefore, an...

Keywords

Multiple Myeloma Chronic Lymphocytic Leukemia Follicular Lymphoma Mantle Cell Lymphoma Keyhole Limpet Hemocyanin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bendandi M (2006) Clinical benefit of idiotype vaccines: too many trials for a clever demonstration? Rev Recent Clin Trials 1:67–74CrossRefPubMedGoogle Scholar
  2. Bendandi M (2009) Idiotype vaccines for lymphoma: proof-of-principles and clinical trial failures. Nat Rev Cancer 9:675–681CrossRefPubMedGoogle Scholar
  3. Bendandi M, Gocke CD, Kobrin CB et al (1999) Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma. Nat Med 5:1171–1177CrossRefPubMedGoogle Scholar
  4. de Cerio AL, Inogés S, Ai WZ, Villanueva H, Pastor F, Soldevilla MM, Soria E, Bendandi M (2013) Successful idiotypic vaccination following stem cell allotransplant in lymphoma. Leuk Lymphoma 54:881–884CrossRefPubMedGoogle Scholar
  5. Inogés S, Rodríguez-Calvillo M, Zabalegui N et al (2006) Clinical benefit associated with idiotypic vaccination in follicular lymphoma. J Natl Cancer Inst 98:1292–1301CrossRefPubMedGoogle Scholar
  6. Inoges S, de Cerio AL, Villanueva H, Pastor F, Bendandi M (2014) Idiotype vaccine production using hybridoma technology. Methods Mol Biol 1139:367–387CrossRefPubMedGoogle Scholar
  7. Kwak LW, Campbell MJ, Czerwinski DK et al (1992) Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N Engl J Med 327:1209–1215CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Hematopoietic stem cell. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1645. doi:10.1007/978-3-642-16483-5_2619Google Scholar
  2. (2012) Hybridomas. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1775. doi:10.1007/978-3-642-16483-5_2884Google Scholar
  3. (2012) Idiotype. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1804. doi:10.1007/978-3-642-16483-5_2944Google Scholar
  4. (2012) Monoclonal antibody. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2367. doi:10.1007/978-3-642-16483-5_6842Google Scholar
  5. (2012) Radioimmunoconjugates. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3148. doi:10.1007/978-3-642-16483-5_4917Google Scholar
  6. (2012) Recombinant. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3205. doi:10.1007/978-3-642-16483-5_4991Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Clinical Medicine, School of MedicineRoss UniversityRoseauCommonwealth of Dominica