Hyperthermia refers to the elevation of temperature above physiological levels, typically to values of 40–45 °C.
Hyperthermia utilizes elevated tissue temperatures, typically between 40 °C and 45 °C, to alter the tumor and normal tissue environment. The goal of hyperthermia in cancer treatment is to create an environment that will aid in eradicating tumor while sparing normal tissue. Hyperthermia accomplishes this by causing direct cytotoxic effects and a variety of physiologic effects, including the alteration of blood flow and oxygenation status. Clinically, hyperthermia can work synergistically with both radiation and chemotherapy.
Hyperthermia elicits cytotoxic effects in tissue through a variety of mechanisms, inducing both apoptosis and necrosis. Above 40 °C, protein is a dominant molecular target, with protein denaturation exhibiting a similar heat of inactivation as thermal cell kill and damage (130–170 kcal/mol). Other cellular...
KeywordsThermal Sensitivity Tumor Metabolism Proton Resonance Frequency Chest Wall Recurrence Water Bolus
- Dewhirst MW, Jones E, Samulski T et al (2006) Hyperthermia. In: Kufe DW, Bast RC, Hait WN, Hong WK, Pollock RE, Weichselbaum RR, Holland JF, Frei E III (eds) Cancer medicine. BC Decker, Hamilton, pp 549–561Google Scholar
- Jones EL, Samulski TV, Vujaskovic Z et al (2004) Hyperthermia. In: Perez CA, Brady LW, Halperin EC, Schmidt-Ullrich RK (eds) Principles and practice of radiation oncology. Lippincott Williams and Wilkins, Philadelphia, pp 699–735Google Scholar