Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Hurthle Cell Adenoma and Carcinoma

  • Ronald A. Ghossein
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2869-2



Hurthle cell adenomas and carcinomas are, respectively, benign and malignant epithelial tumors arising from the follicular epithelium of the thyroid gland, containing at least 75 % of oncocytes and lacking the characteristic nuclear features of papillary thyroid carcinoma (i.e., irregular clear nuclei with grooves, overlapping and pseudo-inclusions). The oncocytes in Hurthle cell adenomas and carcinomas are characterized by an eosinophilic granular cytoplasm on hematoxylin and eosin sections with a vesicular nucleus and a large centrally located nucleolus. The oncocytic nature of the cytoplasm is due in the vast majority of the cases to its high content in mitochondria.

Max Askanazy, a German pathologist (1865–1940), was the first to describe the follicular oncocytic cells of the thyroid in 1898 also known as Hurthle cells.


Clinical and Histopathologic Characteristics....


Papillary Thyroid Carcinoma Vascular Invasion Papillary Carcinoma Radioactive Iodine Follicular Carcinoma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of PathologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA