Huntingtin Interacting Protein 1
HIP1 is the first example of an endocytic adapter protein that is altered in many human cancers. The following summary of HIP1’s role in cancer suggests that HIP1 represents a novel type of oncoprotein that hijacks endocytosis to increase signaling from multiple receptors in parallel to transform normal cells into cancer cells.
HIP1 is a 116 kDa cytosolic protein that was originally identified by yeast two hybrid screening for proteins that interact with huntingtin, the protein whose gene is mutated in Huntington’s disease. HIP1 and its only known mammalian relative, HIP1-related (HIP1r), contain clathrin-binding domains and carboxyl terminal actin-binding TALIN homology domains. HIP1 and HIP1r also contain amino terminal epsin/AP180 N-terminal homology (E/ANTH) domains. These domains bind specific inositol lipids and have been shown to be important in epsin- and AP180-mediated modulation of the growth factor receptor uptake phase of clathrin-mediated...
KeywordsEpidermal Growth Factor Receptor Merkel Cell Carcinoma Membrane Trafficking Tramp Mouse Human HIP1
- (2012) EGFR. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1211. doi: 10.1007/978-3-642-16483-5_1828Google Scholar
- (2012) Prognosis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2994. doi: 10.1007/978-3-642-16483-5_4758Google Scholar