Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Human Herpesvirus 6

  • Dario Di Luca
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2850-2


The family Herpesviridae is comprised of viruses characterized by a distinct morphology. Virion particles are enveloped and have a diameter of ~200 nm. The icosahedral capsid contains a double-stranded linear DNA molecule with a molecular weight of 80–150 million daltons.


According to their biologic and molecular properties, herpesviruses are classified in three subfamilies (Alphaherpesvirinae, Betaherpesvirinae, Gammaherpesvirinae). Humans are the natural host for eight herpesviruses: herpes simplex 1 (HSV-1), herpes simplex 2 (HSV-2), varicella zoster virus (VZV), human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), human herpesvirus 7 (HHV-7), and human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus.

All herpesviruses have the important biologic characteristic of establishing lifelong latent infections within specific cells of the host after primary infection. Latent virus may occasionally...


Herpes Simplex Latent Infection Lymphoproliferative Disease Human Herpesvirus Bone Marrow Transplant Recipient 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Medical SciencesUniversity of FerraraFerraraItaly