Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Human Herpesvirus 6

  • Dario Di Luca
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2850-2

Definition

The family Herpesviridae is comprised of viruses characterized by a distinct morphology. Virion particles are enveloped and have a diameter of ~200 nm. The icosahedral capsid contains a double-stranded linear DNA molecule with a molecular weight of 80–150 million daltons.

Characteristics

According to their biologic and molecular properties, herpesviruses are classified in three subfamilies (Alphaherpesvirinae, Betaherpesvirinae, Gammaherpesvirinae). Humans are the natural host for eight herpesviruses: herpes simplex 1 (HSV-1), herpes simplex 2 (HSV-2), varicella zoster virus (VZV), human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), human herpesvirus 7 (HHV-7), and human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus.

All herpesviruses have the important biologic characteristic of establishing lifelong latent infections within specific cells of the host after primary infection. Latent virus may occasionally...

Keywords

Herpes Simplex Latent Infection Lymphoproliferative Disease Human Herpesvirus Bone Marrow Transplant Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Clark DA (2000) Human herpesvirus 6. Rev Med Virol 10:155–173CrossRefPubMedGoogle Scholar
  2. De Bolle L, Naesens L, De Clercq E (2005) Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev 18:217–245CrossRefPubMedPubMedCentralGoogle Scholar
  3. Dockrell DH (2003) Human herpesvirus 6: molecular biology and clinical features. J Med Microbiol 52:5–18CrossRefPubMedGoogle Scholar
  4. Doniger S, Muralidhar S, Rosenthal LJ (1999) Human cytomegalovirus and human herpesvirus 6 genes that transform and transactivate. Clin Microbiol Rev 12:367–382PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Medical SciencesUniversity of FerraraFerraraItaly