Angiotensin II Signaling
The angiotensin peptides (angiotensins I, II, III, IV, and -(1–7)) are derived from the precursor angiotensinogen by sequential processing proteases such as renin, angiotensin I-converting enzyme (ACE), chymase, and other peptidases. Among these peptides, angiotensin II has been well studied and is shown to be the most biologically active peptide. This peptide hormone production system is called the renin-angiotensin system and is one of the phylogenetically oldest hormone systems that has been conserved throughout evolution. The renin-angiotensin system plays a key role in the maintenance of arterial blood pressure and fluid and electrolyte homeostasis. There are two well-defined receptors of angiotensin II (subtype 1 (AT1) and subtype 2 (AT2)), both of which have seven transmembrane, G-protein coupled receptors and are encoded by different genes (AT1 (agtr1), 3q21–25; AT2 (agtr2), Xq22–23). The major isoform, AT1receptor, is expressed in a wide...
KeywordsEpidermal Growth Factor Receptor Epidermal Growth Factor Receptor Transactivation Ovarian Cancer Malignancy Peptide Hormone Production Positive Ovarian Cancer
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