Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Hormones

  • Rekha Mehta
  • Jayadev Raju
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2817-2

Definition

Hormones are complex chemical messengers that bind with high affinity to specific cellular receptors to activate single or multiple signal transduction pathway(s) leading to growth, differentiation, embryogenesis or other biological processes. More than one hormone may work in concert to fulfill a physiological function. Hormones, through their capacity to influence cell growth and differentiation, may further modify the response of the body to carcinogens, the biological behavior of established tumors, and overall cancer risk. Hormones, therefore, play an important role in both the genesis and treatment of cancer.

Characteristics

Hormone-dependent malignancy has been most extensively studied in steroid hormone responsive organs. The steroid hormones, androgens, estrogens (Estradiol; Estrogenic Hormones and cancer) and progestins (Progestin), are implicated as key regulators in the development and the cancer process in the breast (Breast Cancer), prostate (Prostate Cancer...

Keywords

Androgen Receptor Endometrial Cancer Gastrointestinal Stromal Tumor GnRH Agonist Gastrointestinal Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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See Also

  1. (2012) Risk factor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3310. doi:10.1007/978-3-642-16483-5_5111Google Scholar
  2. (2012) Differentiation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1113. doi:10.1007/978-3-642-16483-5_1616Google Scholar
  3. (2012) Initiation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1865. doi:10.1007/978-3-642-16483-5_3057Google Scholar
  4. (2012) Menopause. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2236. doi:10.1007/978-3-642-16483-5_3636Google Scholar

Copyright information

© Her Majesty the Queen in Right of Canada 2015

Authors and Affiliations

  1. 1.Regulatory Toxicology Research Division, Bureau of Chemical SafetyFood Directorate, HPFB, Health CanadaOttawaCanada