Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Angiogenesis

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_274-2

Synonyms

Definition

Angiogenesis is the formation of new capillary vasculature out of pre-existing blood vessels under the regulation of growth factors and inhibitors. It occurs in physiological (e.g., wound healing, ovulation, placental growth) and pathological (e.g., cancer, arthritis, inflammation) conditions.

Characteristics

The formation of new blood vessels out of pre-existing capillaries, the process that is called angiogenesis, is a sequence of events that is of key importance in a broad array of physiologic and pathologic processes. Normal tissue growth such as in embryonic development, wound healing, and the menstrual cycle is characterized by dependence on new vessel formation for the supply of oxygen and nutrients as well as for removal of waste products. Also, in a large number of different and non-related diseases, formation of new vasculature is involved in abnormal physiology. Among these pathologies are diseases such...

Keywords

Diabetic Retinopathy Crohn Disease Endothelial Cell Migration Receptor Tyrosine Kinase Inhibitor Kinase Inhibitor Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Carmeliet P (2005) Angiogenesis in life, disease and medicine. Nature 438:932–936CrossRefPubMedGoogle Scholar
  2. Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285:1182–1186CrossRefPubMedGoogle Scholar
  3. Folkman J (2006) Angiogenesis. Annu Rev Med 57:1–18CrossRefPubMedGoogle Scholar
  4. Griffioen AW, Molema G (2000) Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 52:237–268PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Angiogenesis Laboratory, Department of PathologyMaastricht UniversityMaastrichtThe Netherlands