Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Herpesvirus-Associated Ubiquitin-Specific Protease De-ubiquitinase

  • Christopher L. Brooks
  • Wei Gu
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2690-2



The cysteine protease de-ubiquitinase (DUB) herpesvirus-associated ubiquitin-specific protease (HAUSP) has been fairly well characterized in recent years and has emerged as an important component of the p53-Mdm2 signaling pathway.


De-ubiquitinases are specific protease enzymes that catalyze the removal of ubiquitin from substrates by cleaving the isopeptide bond between ubiquitin and substrate. The de-ubiquitination enzyme family (DUBs) falls within two classes of proteases: the metalloproteases and cysteine proteases, though most DUBs fall within the latter. Further classification subdivides the cysteine proteases into four subclasses: ubiquitin C-terminal hydrolases (UCH), ubiquitin-specific proteases (USP), Machado-Joseph disease proteases (MJD), and Otubain proteases (OTU). The MJD and OTU subclasses were more recently identified through a bioinformatics approach. MJD is a rare hereditary...


Cysteine Protease Mdm2 Protein Cancer Cell Line HCT116 Colorectal Cancer Cell Line HCT116 Rare Hereditary Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute for Cancer Genetics, and Department of PathologyCollege of Physicians and Surgeons, Columbia UniversityNew YorkUSA