Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Hepatitis C Virus

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2661-2

Synonyms

HCV

Definition

Hepatitis C virus (HCV) belongs to the Flaviviridae family (Hepacivirus genus) and is a pathogenic human RNA virus, which causes chronic liver disease and hepatocellular carcinoma (Hepatocellular Carcinoma, Molecular Biology) (HCC).

Characteristics

The size of this enveloped virus is ∼60 nm. Its nucleocapsid contains a single-stranded RNA genome of ∼9.6 kb genome (Fig. 1) of plus(+) strand polarity that carries a single open reading frame. At least six major genotypes (1–6) with up to three subtypes (a to c) exist, which differ not only in their nucleic acid sequence but also in their pathophysiological properties. All structural and nonstructural viral proteins are processed from a polyprotein precursor of 3010–3033 amino acids in the cytoplasm or endoplasmic reticulum of the infected cell.

Keywords

Soft Agar Growth Intravenous Drug Addiction High Chronicity Rate Hepatocyte Transformation Patient Develop Liver Cirrhosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Moriya K, Fujie H, Fukuda K et al (1998) The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med 4:1065–1067CrossRefPubMedGoogle Scholar
  2. Wedemeyer H, Caselmann WH, Manns MP (1998) Combination therapy of chronic hepatitis C – an important step but not the final goal. J Hepatol 29:1010–1014CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Hepatitis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1663. doi:10.1007/978-3-642-16483-5_2658Google Scholar
  2. (2012) Liver cirrhosis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2067. doi:10.1007/978-3-642-16483-5_3396Google Scholar
  3. (2012) Pegylated interferons. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2805. doi:10.1007/978-3-642-16483-5_4434Google Scholar
  4. (2012) Quasispecies. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3132. doi:10.1007/978-3-642-16483-5_4885Google Scholar
  5. (2012) Transactivation. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3747. doi:10.1007/978-3-642-16483-5_5893Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Medizinische Klinik und Poliklinik IRheinische Friedrich-Wilhelms-UniversitätBonnGermany