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Hepatitis B Virus x Antigen Associated Hepatocellular Carcinoma

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Encyclopedia of Cancer

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Synonyms

HCC; Hepatocellular carcinoma; Liver cancer

Definition

The term hepatitis B x antigen, or HBxAg, refers to the gene product of hepatitis B virus (HBV) that contributes importantly to virus replication, the pathogenesis of chronic liver disease (CLD), and the development of HCC. CLD is the process that involves the immunologically mediated damage or destruction of various cell types within the liver. CLD encompasses hepatitis (inflammation of the liver), fibrosis (scarring, which involves the accumulation of connective tissue in the place of liver tissue), and cirrhosis (extensive scarring in which connective tissues completely surrounds islands of remaining liver tissue).

Characteristics

There are an estimated 350 million people worldwide who are chronically infected with HBV and often replicate virus for many years or decades. These people are at high risk for the development of chronic hepatitis, which may progress onto cirrhosis (end stage liver disease) and then HCC....

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References

  • Arbuthnot P, Capovilla A, Kew M (2000) Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways. J Gastroenterol Hepatol 15:357–368

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  • Feitelson MA (2004) Molecular and genetic determinants of primary liver malignancy. In: Khatri VP, Schneider PD (eds) Surgical clinics of North America, vol 84, Liver surgery: modern concepts and techniques. WB Saunders, Philadelphia, pp 339–354

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  • Jin YM, Yun C, Park C et al (2001) Expression of hepatitis B virus X protein is closely correlated with the high periportal inflammatory activity of liver diseases. J Viral Hepat 8:322–330

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  • Waris G, Siddiqui A (2003) Regulatory mechanisms of viral hepatitis B and C. J Biosci 28:311–321

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Author information

Authors and Affiliations

  1. Department of Biology, Temple University, Philadelphia, PA, USA

    Mark A. Feitelson

Authors
  1. Mark A. Feitelson
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Corresponding author

Correspondence to Mark A. Feitelson .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2014 Springer-Verlag Berlin Heidelberg

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Feitelson, M.A. (2014). Hepatitis B Virus x Antigen Associated Hepatocellular Carcinoma. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_2660-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_2660-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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