Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Helicobacter Pylori in the Pathogenesis of Gastric Cancer

  • Wenbo Meng
  • Yan Li
  • Liang Qiao
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2606-5


The discovery of Helicobacter pylori (H. pylori) and its causal relationship with gastrointestinal disorders has revolutionized our understanding of the pathogenesis of several common gastrointestinal disorders particularly chronic gastritis, dyspepsia, GERD, gastric and duodenal ulcers, and gastric cancer (GC). More importantly, identification of H. pylori as a key etiological factor for peptic ulcers and gastric cancer has led to the development of more specific and effective therapies for gastric ulcer and a certain type of malignant disorder such as gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). The World Health Organization (WHO) has classified H. pylori as the most important of the known etiological factors for gastric cancer (Class I carcinogen). Considering gastric cancer being one of the most common malignant tumors and the second leading cause of cancer-related deaths worldwide, and H. pyloriis not only the most important single cause for the...


Gastric Cancer Pylorus Infection Migration Inhibitory Factor Intestinal Metaplasia Malt Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Amieva MR, El-Omar EM (2008) Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology 134:306–323CrossRefPubMedGoogle Scholar
  2. Gisbert JP, de la Morena F, Abraira V (2006) Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection: a systematic review and meta-analysis. Am J Gastroenterol 101:1921–1930CrossRefPubMedGoogle Scholar
  3. Hur K, Niwa T, Toyoda T, Tsukamoto T, Tatematsu M, Yang HK, Ushijima T (2011) Insufficient role of cell proliferation in aberrant dna methylation induction and involvement of specific types of inflammation. Carcinogenesis 32:35–41CrossRefPubMedGoogle Scholar
  4. Iammarino NK, Gribble G (2009) The intercultural cancer council’s fact sheet series: a tool for public and professional education. J Cancer Educ 24:S7–S9CrossRefPubMedGoogle Scholar
  5. Kiga K, Mimuro H, Suzuki M, Shinozaki-Ushiku A, Kobayashi T, Sanada T, Kim M, Ogawa M, Iwasaki YW, Kayo H, Fukuda-Yuzawa Y, Yashiro M, Fukayama M, Fukao T, Sasakawa C (2014) Epigenetic silencing of mir-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection. Nat Commun 5:4497PubMedCentralCrossRefPubMedGoogle Scholar
  6. Kuipers EJ, Thijs JC, Festen HP (1995) The prevalence of Helicobacter pylori in peptic ulcer disease. Aliment Pharmacol Ther 9:59–69PubMedGoogle Scholar
  7. Kusters JG, van Vliet AH, Kuipers EJ (2006) Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 19:449–490PubMedCentralCrossRefPubMedGoogle Scholar
  8. Lin LL, Huang HC, Ogihara S, Wang JT, Wu MC, McNeil PL, Chen CN, Juan HF (2012) Helicobacter pylori disrupts host cell membranes, initiating a repair response and cell proliferation. Int J Mol Sci 13:10176–10192PubMedCentralCrossRefPubMedGoogle Scholar
  9. Malfertheiner P, Megraud F, O’Morain C, Bazzoli F, El-Omar E, Graham D, Hunt R, Rokkas T, Vakil N, Kuipers EJ (2007) Current concepts in the management of Helicobacter pylori infection: the Maastricht III consensus report. Gut 56:772–781PubMedCentralCrossRefPubMedGoogle Scholar
  10. Matsuo T, Ito M, Takata S, Tanaka S, Yoshihara M, Chayama K (2011) Low prevalence of Helicobacter pylori-negative gastric cancer among Japanese. Helicobacter 16:415–419CrossRefPubMedGoogle Scholar
  11. Ohnishi S, Ma N, Thanan R, Pinlaor S, Hammam O, Murata M, Kawanishi S (2013) DNA damage in inflammation-related carcinogenesis and cancer stem cells. Oxid Med Cell Longev 2013:387014PubMedCentralCrossRefPubMedGoogle Scholar
  12. Ou Y, Kang M, Zhou L, Cheng Z, Tang S, Yu D (2014) Infection with L-form of Helicobacter pylori and expressions of MIF, MMP9 and VEGF in gastric carcinoma. J South Med Univ 34:180–187Google Scholar
  13. Peterson AJ, Menheniott TR, O’Connor L, Walduck AK, Fox JG, Kawakami K, Minamoto T, Ong EK, Wang TC, Judd LM, Giraud AS (2010) Helicobacter pylori infection promotes methylation and silencing of Trefoil Factor 2, leading to gastric tumor development in mice and humans. Gastroenterology 139:2005–2017PubMedCentralCrossRefPubMedGoogle Scholar
  14. Sepulveda AR, Yao Y, Yan W, Park DI, Kim JJ, Gooding W, Abudayyeh S, Graham DY (2010) Cpg methylation and reduced expression of O6-methylguanine DNA methyltransferase is associated with Helicobacter pylori infection. Gastroenterology 138:1836–1844CrossRefPubMedGoogle Scholar
  15. Take S, Mizuno M, Ishiki K, Nagahara Y, Yoshida T, Yokota K, Oguma K, Okada H, Shiratori Y (2005) The effect of eradicating Helicobacter pylori on the development of gastric cancer in patients with peptic ulcer disease. Am J Gastroenterol 100:1037–1042CrossRefPubMedGoogle Scholar
  16. Wang AY, Peura DA (2011) The prevalence and incidence of Helicobacter pylori-associated peptic ulcer disease and upper gastrointestinal bleeding throughout the world. Gastrointest Endosc Clin N Am 21:613–635CrossRefPubMedGoogle Scholar
  17. Yoon H, Kim N, Lee HS, Shin CM, Park YS, Lee DH, Jung HC, Song IS (2011) Helicobacter pylori-negative gastric cancer in South Korea: incidence and clinicopathologic characteristics. Helicobacter 16:382–388CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Special Minimally Invasive Surgery, Hepatopancreatobiliary Surgery Institute of Gansu Province, Clinical Medical College Cancer CenterFirst Hospital of Lanzhou University, Lanzhou UniversityLanzhouChina
  2. 2.Department of ImmunologyCleveland ClinicClevelandUSA
  3. 3.Storr Liver Centre, Westmead Millennium Institute for Medical ResearchThe University of Sydney at Westmead HospitalWestmeadAustralia