Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Helicobacter Pylori in the Pathogenesis of Gastric Cancer

  • Wenbo Meng
  • Yan Li
  • Liang Qiao
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2606-5

Definition

The discovery of Helicobacter pylori (H. pylori) and its causal relationship with gastrointestinal disorders has revolutionized our understanding of the pathogenesis of several common gastrointestinal disorders particularly chronic gastritis, dyspepsia, GERD, gastric and duodenal ulcers, and gastric cancer (GC). More importantly, identification of H. pylori as a key etiological factor for peptic ulcers and gastric cancer has led to the development of more specific and effective therapies for gastric ulcer and a certain type of malignant disorder such as gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). The World Health Organization (WHO) has classified H. pylori as the most important of the known etiological factors for gastric cancer (Class I carcinogen). Considering gastric cancer being one of the most common malignant tumors and the second leading cause of cancer-related deaths worldwide, and H. pyloriis not only the most important single cause for the...

Keywords

Gastric Cancer Pylorus Infection Migration Inhibitory Factor Intestinal Metaplasia Malt Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Special Minimally Invasive Surgery, Hepatopancreatobiliary Surgery Institute of Gansu Province, Clinical Medical College Cancer CenterFirst Hospital of Lanzhou University, Lanzhou UniversityLanzhouChina
  2. 2.Department of ImmunologyCleveland ClinicClevelandUSA
  3. 3.Storr Liver Centre, Westmead Millennium Institute for Medical ResearchThe University of Sydney at Westmead HospitalWestmeadAustralia