Helicobacter Pylori in the Pathogenesis of Gastric Cancer
The discovery of Helicobacter pylori (H. pylori) and its causal relationship with gastrointestinal disorders has revolutionized our understanding of the pathogenesis of several common gastrointestinal disorders particularly chronic gastritis, dyspepsia, GERD, gastric and duodenal ulcers, and gastric cancer (GC). More importantly, identification of H. pylori as a key etiological factor for peptic ulcers and gastric cancer has led to the development of more specific and effective therapies for gastric ulcer and a certain type of malignant disorder such as gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). The World Health Organization (WHO) has classified H. pylori as the most important of the known etiological factors for gastric cancer (Class I carcinogen). Considering gastric cancer being one of the most common malignant tumors and the second leading cause of cancer-related deaths worldwide, and H. pyloriis not only the most important single cause for the...
KeywordsGastric Cancer Pylorus Infection Migration Inhibitory Factor Intestinal Metaplasia Malt Lymphoma
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