Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Hedgehog Signaling

  • Carol Wicking
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2602-2

Definition

The Hedgehog pathway is a signaling cascade that plays a crucial role in the embryonic development of a wide range of vertebrate organs and systems. Mutations in members of the Hedgehog pathway have been found in a number of tumor types including basal cell carcinoma (BCC) and medulloblastoma. More recently, ligand-dependent activation of the pathway has been demonstrated in a wider range of tumors. Although some differences exist, the overall pathway has been conserved from Drosophila through to human.

Characteristics

The Hedgehog proteins are secreted molecules that act through a receptor complex involving two additional proteins Patched and Smoothened. The current model for Hedgehog signaling suggests that in the absence of Hedgehog, Patched inhibits Smoothened and thus prevents signaling. When Hedgehog binds to Patched, the inhibition of Smoothened is released and intracellular signaling is activated. The ultimate regulation of Hedgehog target genes in the nucleus is...

Keywords

Esophageal Squamous Cell Carcinoma Basal Cell Carcinoma Hedgehog Signaling Hedgehog Pathway Nevoid Basal Cell Carcinoma Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  2. Robbins DJ, Hebrok M (2007) Hedgehogs: la dolce vita. Workshop on Hedgehog-Gli signaling in cancer and stem cells. EMBO Rep 8:451–455PubMedCentralCrossRefPubMedGoogle Scholar
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  5. Wicking C, McGlinn E (2001) The role of hedgehog signaling in tumorigenesis. Cancer Lett 173:1–7CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Cancer stem cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 626. doi:10.1007/978-3-642-16483-5_815Google Scholar
  2. (2012) Cyclopamine. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1036. doi:10.1007/978-3-642-16483-5_1438Google Scholar
  3. (2012) Gli. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1552. doi:10.1007/978-3-642-16483-5_2418Google Scholar
  4. (2012) Hedgehog. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1636. doi:10.1007/978-3-642-16483-5_2601Google Scholar
  5. (2012) Patched. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2792. doi:10.1007/978-3-642-16483-5_4403Google Scholar
  6. (2012) Smoothened. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3456. doi:10.1007/978-3-642-16483-5_5383Google Scholar
  7. (2012) Suppressor of fused. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3568. doi:10.1007/978-3-642-16483-5_5585Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institute for Molecular BioscienceThe University of QueenslandSt LuciaAustralia