Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Michael R. Freeman
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2579-2


Heparin-binding epidermal growth factor-like growth factor is a high-affinity, activating ligand for the epidermal growth factor receptor (EGFR/HER1/ErbB1) and for the related receptor tyrosine kinase, ErbB4. HB-EGF was originally identified by a combination of biochemical and bioactivity-based in vitro assays. Following biochemical purification, the protein was recognized as a member of the epidermal growth factor (EGF) family by molecular cloning. The HB-EGF gene resides on chromosome 5 (5q23) in the human genome.


HB-EGF is a mitogen, morphogen, motility, and cell survival factor. The protein is initially expressed in a membrane-anchored form (proHB-EGF), with a single membrane-spanning domain, a structural characteristic shared by other ErbB family ligands. HB-EGF was initially observed as a mitogenic activity recognizable in cell culture medium conditioned by macrophage-like cells. The protein was recognized to have a high affinity for immobilized...


Diphtheria Toxin Cell Surface Heparan Sulfate Cell Surface Heparan Sulfate Proteoglycan Immobilize Heparin Juxtacrine Signaling 
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  1. Adam RM, Danciu T, McLellan DL et al (2003) A nuclear form of the heparin-binding epidermal growth factor-like growth factor precursor is a feature of aggressive transitional carcinoma. Cancer Res 63:484–490PubMedGoogle Scholar
  2. Nishi E, Klagsbrun M (2004) Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a mediator of multiple physiological and pathological pathways. Growth Factors 22:253–260CrossRefPubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Urological Diseases Research CenterChildren’s Hospital Boston, Harvard Medical SchoolBostonUSA