Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

HB-EGF

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2579-2

Definition

Heparin-binding epidermal growth factor-like growth factor is a high-affinity, activating ligand for the epidermal growth factor receptor (EGFR/HER1/ErbB1) and for the related receptor tyrosine kinase, ErbB4. HB-EGF was originally identified by a combination of biochemical and bioactivity-based in vitro assays. Following biochemical purification, the protein was recognized as a member of the epidermal growth factor (EGF) family by molecular cloning. The HB-EGF gene resides on chromosome 5 (5q23) in the human genome.

Characteristics

HB-EGF is a mitogen, morphogen, motility, and cell survival factor. The protein is initially expressed in a membrane-anchored form (proHB-EGF), with a single membrane-spanning domain, a structural characteristic shared by other ErbB family ligands. HB-EGF was initially observed as a mitogenic activity recognizable in cell culture medium conditioned by macrophage-like cells. The protein was recognized to have a high affinity for immobilized...

Keywords

Diphtheria Toxin Cell Surface Heparan Sulfate Cell Surface Heparan Sulfate Proteoglycan Immobilize Heparin Juxtacrine Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access

References

  1. Adam RM, Danciu T, McLellan DL et al (2003) A nuclear form of the heparin-binding epidermal growth factor-like growth factor precursor is a feature of aggressive transitional carcinoma. Cancer Res 63:484–490PubMedGoogle Scholar
  2. Nishi E, Klagsbrun M (2004) Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a mediator of multiple physiological and pathological pathways. Growth Factors 22:253–260CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Urological Diseases Research CenterChildren’s Hospital Boston, Harvard Medical SchoolBostonUSA