Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Grape Seed Extract

  • Manjinder Kaur
  • Rajesh Agarwal
  • Chapla Agarwal
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_2510-2

Definition

Grape seed extract is a nutraceutical rich in grape seed proanthocyanidins. It is widely consumed for its beneficial health effects attributed to its high proanthocyanidin(s) content. Extract is prepared from the seeds of the grapes (Vitis vinifera), and seeds are usually procured from wine or juice industry where they are generated as major by-product and/or waste product. Standardized preparations are sold throughout the world and are usually marketed as health supplement.

Characteristics

Grape seed extract is a complex mixture of polyphenols (includes phenolic acids, colored anthocyanins, flavonoids, and complex flavonoids). It is particularly rich in proanthocyanidins. Chemically, proanthocyanidins in turn encompass two major chemical constituents: procyanidins and procyanidin gallates. Procyanidins are basically oligomeric or polymeric flavonols, consisting of (+)-catechin and (−)-epicatechin, whereas procyanidin gallates are mainly (−)-epicatechin acetylated with...

Keywords

Epidermal Growth Factor Receptor Grape Seed Grape Seed Extract Health Beneficial Effect Health Supplement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bagchi D, Bagchi C, Stohs SJ et al (2000) Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148:187–197CrossRefPubMedGoogle Scholar
  2. Kaur M, Singh RP, Gu M et al (2006) Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clin Cancer Res 12:6194–6202CrossRefPubMedGoogle Scholar
  3. Kijima I, Phung S, Hur G et al (2006) Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res 66:5960–5967CrossRefPubMedGoogle Scholar
  4. Shi J, Yu J, Pohorly JE et al (2003) Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291–299CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Adhesion Molecules. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 66. doi: 10.1007/978-3-642-16483-5_96Google Scholar
  2. (2012) Androgens. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 178. doi: 10.1007/978-3-642-16483-5_268Google Scholar
  3. (2012) Anthocyanins. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 202. doi: 10.1007/978-3-642-16483-5_299Google Scholar
  4. (2012) Antioxidant. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 216. doi: 10.1007/978-3-642-16483-5_328Google Scholar
  5. (2012) Aromatase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 276. doi: 10.1007/978-3-642-16483-5_394Google Scholar
  6. (2012) Estrogens. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1333. doi: 10.1007/978-3-642-16483-5_2019Google Scholar
  7. (2012) Grape Seed Proanthocyanidins. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1602. doi: 10.1007/978-3-642-16483-5_2511Google Scholar
  8. (2012) Low Density Lipoprotein. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2076. doi: 10.1007/978-3-642-16483-5_3417Google Scholar
  9. (2012) Vitamin C. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3925. doi: 10.1007/978-3-642-16483-5_6206Google Scholar
  10. (2012) Vitamin E. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3928. doi: 10.1007/978-3-642-16483-5_6209Google Scholar
  11. (2012) Xenograft. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3967. doi: 10.1007/978-3-642-16483-5_6278Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Manjinder Kaur
    • 1
  • Rajesh Agarwal
    • 2
  • Chapla Agarwal
    • 3
  1. 1.Department of Pharmaceutical SciencesSchool of Pharmacy, University of Colorado Health Sciences CenterDenverUSA
  2. 2.Department of Pharmaceutical SciencesSkaggs School of Pharmacy and Pharmaceutical Sciences, University of ColoradoAuroraUSA
  3. 3.SOP-AdministrationUniversity of Colorado Denver – Anschutz Medical CampusAuroraUSA