Living reference work entry
The anthracyclines that have been tested clinically so far have been limited to those produced by fermentation or semi-synthetic processes. In contrast, 9-aminoanthracycline oramrubicin is a fully synthetic drug. Amrubicin differs from daunosamine in that it contains a 9-amino group and a simple sugar moiety (Fig. 1).
KeywordsFebrile Neutropenia Maximum Tolerate Dose Overall Response Rate Sensitive Group SCLC Patient
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- O’Brien ME, Konopa K, Lorigan P et al (2011) Randomised phase II study of amrubicin as single agent or in combination with cisplatin versus cisplatin etoposide as first-line treatment in patients with extensive stage small cell lung cancer – EORTC 08062. Eur J Cancer 47:2322–2330CrossRefPubMedGoogle Scholar
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